Endocrine Abstracts

Extracellular proteolytic cleavage of insulin receptor (IR) and the generation of soluble insulin receptor (sIR) is a response of the liver and fat associated with physiological conditions and metabolic alterations mainly related to hyperinsulinemia. However, cleavage of this receptor has not been analyzed in skeletal muscle, a central tissue in insulin-mediated glucose homeostasis. This study aimed to analyze the insulin receptor subunits in the gastrocnemius and soleus muscl...

Metabolic syndrome (MS) is a group of signs that increase the risk of developing cardiovascular diseases and type 2 diabetes mellitus (DM2). MS includes at least 3 of these signs: central obesity, dyslipidemia, hypertension, fasting glucose disorders, and insulin resistance. The consumption of sugar drinks, a high-calorie diet, a sedentary lifestyle, and environmental pollutants such as arsenic increase the risk of developing MS. Arsenic affects beta-cell function and insulin ...