Endocrine Abstracts

This female patient presented acutely with headache and neck pain associated with vomiting. Neurological examination was normal. Urine pregnancy test prior to imaging was unexpectedly positive. CT head demonstrated a 2.5x1.5 cm hyperattenuating lesion at the left frontoparietal region. Thyroid function tests were in keeping with thyrotoxicosis (TSH <0.01 mU/l, free T4 37.2 pmo/l, free T3 >30.7 pmo/l). Antithyroid medication was commenced and TSH receptor antibody reque...

This 60-year-old male was reviewed remotely for follow up in the general endocrine outpatient clinic having originally been referred for erectile dysfunction and low libido. He had a past medical history of hypertension and dyslipidaemia and was prescribed amlodipine and atorvastatin. On previous clinical assessments, he had increased muscle bulk, normal secondary sexual characteristics with testes measuring 15mls and 12mls. There had been no evidence of gynaecomastia. He work...

This 31 year old patient was referred to the endocrinology department with a history of dizziness and fatigue. Past medical history identified that he had been diagnosed with congenital adrenal hyperplasia, presumed to be secondary to 21-hydroxylase deficiency, by 18 months of age whilst living abroad. He had been raised as a male but was found to have 46XX genotype with grade 5 virilisation. During childhood and early adolescence, he underwent multiple operations to remove Mu...

Peripartum hyponatraemia is an under-recognised complication of labour and poses a risk to both mother and baby. It is typically caused by water intoxication for physiological reasons and population health trends around water intake. We have recent experience of managing 2 patients with severe symptomatic hyponatraemia. Both patients had increased their oral intake of fluid during labour as well as receiving intravenous fluids. Dilutional hyponatraemia was found to be the unde...

Background: Genetic causes of hypocalcaemia can be overlooked in patients presenting without apparent syndromic features. One such example is DiGeorge syndrome, which is often diagnosed in childhood but rarely in adulthood.Case presentation: A 21-year-old lady was referred to our endocrinology clinic regarding chronic hypocalcaemia (adjusted calcium 1.98 mmol/l). This was first diagnosed at the age of eight with no clear cause identified. Her past medica...

Background: Pituitary apoplexy is one of the rare endocrine emergencies. Most series indicate that incidence is between 2-7% based on clinical, surgical and histopathological evidence.1-3 Usually presents with severe headaches that may be associated with nausea vomiting, ocular palsies, fever, photophobia. Predisposing factors are pre-existing pituitary conditions, hypertension, major surgery, anticoagulation therapy, pregnancy, radiotherapy. Appropriate endocrine, ...

Introduction: Neuroendocrine neoplasms (NENs) have variable biological behavior but the majority exhibits a slow progression. Metastatic bone disease (mBD) in NENs is relatively uncommon and not well described albeit associated with an increased mortality.Methods: Seventy-four [37 males (50%), aged(±S.D.) 60.2±19.3] patients with NENs and bone metastases were recruited from 4 centers.Results: Seventy-three ...