Searchable abstracts of presentations at key conferences in endocrinology

ea0081p481 | Thyroid | ECE2022

Unexpected alterations in thyroid status: a case of alemtuzumab-induced Graves’ disease with fluctuating course

Filipa Araujo Barbara , Lavrador Mariana , Araujo Catia , Ribeiro Ana , Paiva Sandra , Paiva Isabel

Introduction: Alemtuzumab is a humanized anti-CD52 monoclonal antibody approved for the treatment of relapsing−remitting multiple sclerosis (RRMS). Through an immune reconstitution mechanism, it leads to thyroid autoimmunity in 35% of cases, with Graves’ disease (GD) being the most common presentation. Alemtuzumab-induced GD exhibits distinctive clinical and immunological features, with rarely reported cases of fluctuating thyroid status with documented both blockin...

ea0081ep165 | Calcium and Bone | ECE2022

Reduced bone mineral density in primary adrenal insufficiency: consequences of long-term treatment

Araujo Barbara Filipa , Lavrador Mariana , Araujo Catia , Ferreira Mafalda , Barros Luisa , Paiva Sandra , Paiva Isabel

Introduction: The effects of long-term replacement therapy of primary adrenal insufficiency (PAI) are still a matter of debate. Glucocorticoid (GC) replacement regimens do not completely mimic the endogenous hormonal production and their monitoring is sometimes difficult. Therefore, some patients are exposed to mild GC excess with potential complications, such as hypertension, diabetes, and skeletal fragility. Data on bone mineral density (BMD) in PAI is still scarce and contr...

ea0040p20 | (1) | ESEBEC2016

The importance of fully investigating adrenal incidentaloma: two pheochromocytoma cases

Oliveira Diana , Paiva Sandra , Paiva Isabel , Rodrigues Dircea , Guelho Daniela , Cardoso Luis , Vicente Nuno , Martins Diana , Lages Adriana , Ventura Mara , Carrilho Francisco

Introduction: In most cases, adrenal incidentalomas are non-functioning adrenocortical adenomas, but may also represent conditions in which therapeutic intervention is essential, such as pheochromocytomas, even with low index of suspicion.Case reports: Case report 1. Fifty-three-year-old male with history of arterial hypertension (HT), type 2 diabetes Mellitus and myocardial infarction, with a right adrenal incidentaloma found in abdomi...

ea0037ep772 | Pituitary: clinical | ECE2015

Indirect immunofluorescence for detection of pituitary antibodies

Vicente Nuno , Taylor Monica , Barros Luisa , Gomes Leonor , Rodrigues Dircea , Paiva Sandra , Paiva Isabel , Guelho Daniela , Cardoso Luis , Martins Diana , Oliveira Diana , Caturegli Patrizio , Carrilho Francisco

Introduction: Definitive diagnosis of lymphocytic hypophisitis (LH) lacks a pathological analysis. The detection of pituitary antibodies (PAB) with the current methods presents variable results and its clinical utility is therefore limited. Recently, new methods were released for the interpretation of indirect immunofluorescence (IIF), which can increase the specificity for detection of PAB.Methods: We evaluated four patients followed in endocrinology co...

ea0056p883 | Pituitary - Clinical | ECE2018

Pituitary apoplexy: 15 years of experience

Marques Bernardo , Oliveira Diana , Ventura Mara , Lages Adriana , Cunha Nelson , Catarino Diana , Fadiga Lucia , Bastos Margarida , Paiva Sandra , Paiva Isabel , Gomes Leonor , Carrilho Francisco

Introduction: Pituitary apoplexy (PA) is an endocrine emergency and usually presents with sudden headache and visual fields changes. Pituitary function assessment should be performed promptly and repeated throughout follow-up, regardless of the choice of treatment.Methods/design: Retrospective analysis of patients diagnosed with PA admitted to an Endocrinoloy Department of a tertiary hospital between 2002 and 2017. Review of patients’ medical record...

ea0073aep96 | Calcium and Bone | ECE2021

Normocalcemic primary hyperparathyroidism – an early stage of hypercalcemic hyperparathyroidism?

Bárbara Filipa Araújo , Ferreira Sara Esteves , Rodrigues Teresa , Cátia Andreia Araújo , Lúcia Fadiga , Paiva Sandra , PAIVA Isabel

IntroductionPrimary hyperparathyroidism (PHPT) is a common endocrine disorder and classically associated with hypercalcemia (HHPT). There is a newest variant of PHPT, defined by normal albumin-corrected calcium levels - normocalcemic PHPT (NHPT) – which may represent an early stage of HHPT. Nevertheless, there is limited data on how this variant presents clinically and biochemically.AimTo evaluate the de...

ea0073aep198 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Elderly patients with Type 2 Diabetes and Covid-19: the impact of glycemic control on the outcomes

Cátia Andreia Araújo , Bárbara Filipa Araújo , Melo Miguel , Baptista Carla , Paiva Sandra , Paiva Isabel

IntroductionDiabetes mellitus (DM) is one of the major comorbidities in patients with Coronavirus disease (COVID-19) leading to poorer outcomes. Previous evidence showed that poorly-controlled hyperglycemia increases the severity and mortality of COVID-19. Nevertheless, there is limited data on the role of in-hospital glucose control on the outcomes of elderly patients with type 2 diabetes mellitus (T2DM).Objective<p class="abs...

ea0073aep273 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Acute hyperglycemic emergencies during lockdown: COVID-19 collateral damage

Bárbara Filipa Araújo , Cátia Andreia Araújo , Lavrador Mariana , Elvas Ana Rita , Paiva Sandra , PAIVA Isabel

IntroductionIn march 2020, the COVID-19 pandemic registered its first cases in Portugal, leading the government to impose lockdown, in order to prevent the spread of cases. With social isolation and outpatient activity being ceased, there was an increase in mortality of non-COVID patients. The lockdown recommendations are in contradiction with comprehensive diabetes care and reflected in less regular patient-provider interactions, which in some cases con...

ea0073aep247 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Clinical characteristics and outcomes of elderly type 2 diabetic patients with SARS-COV2 infection: a retrospective single centre study

Bárbara Filipa Araújo , Cátia Andreia Araújo , Melo Miguel , Lavrador Mariana , Elvas Ana Rita , Diana Alexandra Festas Silva , Guiomar Joana Reis , Paiva Sandra , PAIVA Isabel

IntroductionDiabetes mellitus (DM) and older age are frequent comorbidities as well as factors associated with poorer outcomes in patients with Coronavirus disease (COVID-19). The reason for worse prognosis in patients with diabetes is likely to be multifactorial.Objectives We aimed to evaluate clinical characteristics and their impact on the outcomes of elderly patients with and without DM hospitalized with ...

ea0016p523 | Obesity | ECE2008

Obesity in GDM: a registry of GDM in Portugal

Ruas Luisa , Paiva Sandra , Rocha Tiago , Dores Jorge , Carvalheiro Manuela

Introduction: A retrospective study of the year 2003, of 1314 women with GDM, from 24 public health Centres in Portugal, was performed.Patients and methods: Women were divided into two groups according to their pre-pregnancy BMI: group Go – BMI ≥30 kg/m2 and group Gno BMI <30 kg/m2. The mean age of these women was 32.9±5 years (18–45), the A1c was <6% in both groups. The influence of the BMI in different...