Searchable abstracts of presentations at key conferences in endocrinology

ea0016oc2.7 | Thyroid | ECE2008

Impact of resistance to thyroid hormone on the cardiovascular system in adult humans

Pulcrano Melania , Mannavola Deborah , Palmieri Emiliano A , Campi Irene , Ciulla Michele , Michi Riccardo , Ippolito Serena , Lombardi Gaetano , Biondi Bernadette , Beck-Peccoz Paolo

Background: Resistance to thyroid hormone (RTH) is an inherited condition of reduced tissue responsiveness to thyroid hormone (TH), biochemically characterized by elevated serum TH concentrations, with inappropriate, non-suppressed thyrotropin levels (TSH). It is caused by point mutations in the ligand binding domain of the TH receptor (TR) β gene, and the mutant TR interferes with the function of the normal TRs (dominant negative effect). The clinical manifestations of R...