Endocrine Abstracts

Background: Survival rate after childhood cancer has improved markedly and today more than 80% of patients with a pediatric malignancy will become 5-year survivor. During the past years it has become evident that many childhood cancer survivors suffer from late complications due to the radiotherapy and chemotherapy. It is established that the largest childhood cancer group, the acute lymphoblastic leukemia (ALL) survivors, exposed to cranial radiotherapy are at particularly hi...

Background/objectives: Hypothalamic obesity (HO) occurs in 50% of patients with the pituitary tumor Craniopharyngioma (CP). Attempts have been made to predict the risk of HO based on hypothalamic (HT) damage on magnetic resonance imaging (MRI), but none have included volumetry. Qualitative and quantitative (volumetric) analyses of HT damage was performed. The results were explored in relation to feeding related peptides and body fat.Subjects/methods: A c...