Searchable abstracts of presentations at key conferences in endocrinology

ea0081rc12.6 | Rapid Communications 12: Reproductive and Developmental Endocrinology | ECE2022

Is Turner syndrome at risk for thyroid carcinoma?

Belardinelli Elisabetta , Dionese Paola , Cecchetti Carolina , Vicennati Valentina , Repaci Andrea , Pagotto Uberto , Gambineri Alessandra

Background: Many questions concerning Turner Syndrome (TS) remain unresolved, such as the long-term complications and, therefore, the optimal care setting for adults. Most controversials regard tumors. Very few data are available on thyroid carcinoma and no specific screening protocol of monitoring is advised in the current official guidelines. This long-term cohort study was primarily aimed at estimating the incidence and time to comorbid conditions along the life course, inc...

ea0090p714 | Reproductive and Developmental Endocrinology | ECE2023

Newly diagnosed diabetes in Turner syndrome: what is the role of incretins?

Cecchetti Carolina , Dionese Paola , Belardinelli Elisabetta , Rotolo Laura , Solmi: Beatrice , Fanelli Flaminia , Pagotto Uberto , Gambineri Alessandra

Introduction: Diabetes mellitus (DM) develops early in Turner syndrome (TS) and appears not related to common risk factors. The precise mechanism of its development is still a matter of debate: a defective insulin response seems to be involved, but the role of incretins is still undefined.Objective: To evaluate the implication of incretin release in the early stages of DM development in TS. Materials and Methods: 153 Turner patient...

ea0081p340 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Excellent disease control in Berardinelli Seip type 1 patient through dietary therapy alone: only an exception?

Cecchetti Carolina , Belardinelli Elisabetta , Dionese Paola , Teglia Rita , Di Cintio Ilaria , D'apice Maria Rosaria , Pagotto Uberto , Gambineri Alessandra

Background and Objective: Severe metabolic complications generally manifest at an early age in Berardinelli – Seip congenital lipodystrophy (BSCL) and their management is especially challenging, often requiring prompt pharmacological treatment with insulin-sensitizers, lipid lowering drugs, insulin and eventually metreleptin. Nutritional intervention with low lipid personalized diets is considered by experts a fundamental tool in handling the disease when associated with ...

ea0090rc4.2 | Rapid Communications 4: Reproductive and Developmental Endocrinology | ECE2023

Evolution of cardiovascular risk markers in polycystic ovary syndrome: Results from a long-term monocentric cohort study

Cecchetti Carolina , Pandurevic Srdjan , Dionese Paola , Belardinelli Elisabetta , Rotolo Laura , Fanelli Flaminia , Bergamaschi Luca , Pizzi Carmine , Pagotto Uberto , Gambineri Alessandra

Background: Many questions concerning polycystic ovary syndrome (PCOS) remain unsolved, such as the long term evolution of cardiovascular (CV) risk markers and the risk for CV events.Methods: A total of 119 PCOS patients diagnosed in 2009 by NIH criteria at our Unit were evaluated at baseline for cardiovascular risk markers (hypertension, diabetes mellitus-DM, dyslipidaemia, obesity, carotid intima media thickness-cIMT, and epicardial fat thickness-EFT) ...

ea0090p462 | Reproductive and Developmental Endocrinology | ECE2023

Remission of ovarian hyperandrogenism in two post-menopausal women treated with GnRH analogue

Dionese Paola , Rotolo Laura , Bongiorno Claudio , Cecchetti Carolina , Starace Michela , Bruni Francesca , Pagotto Uberto , Gambineri Alessandra , Pelusi Carla

Background and aim: Ovarian hyperandrogenism is a known cause of post-menopausal hirsutism and virilisation, more frequently of a benign nature (e.g. ovarian hyperthecosis, Leydig cell hyperplasia). Bilateral salpingo-oophorectomy delivers both definitive diagnostic and therapeutic results. However, after excluding the presence of a suspicious ovarian mass, the use of GnRH analogues (GnRH-a) offers a valuable therapeutic alternative with cases reporting a sustained response in...

ea0081p193 | Reproductive and Developmental Endocrinology | ECE2022

Efficacy of very low calorie ketogenic diet in obese PCOS: a randomized controlled study

Pandurevic Srdjan , Dionese Paola , Mancini Ilaria , Mitselman Dmitri , Magagnoli Matteo , Teglia Rita , Gazineo Domenica , Godino Lea , Fanelli Flaminia , Cristina Meriggiola Maria , Pagotto Uberto , Gambineri Alessandra

Background: Very low-calorie ketogenic diet (VLCKD) was shown to be effective in reducing weight and insulin resistance (IR) in obese patients. Considering that IR is very common in women with polycystic ovary syndrome (PCOS), and that IR worsens hyperandrogenism, ovulatory disfunction, and body fat accumulation, conceivably VLCKD could alleviate PCOS manifestations in the obese phenotype.Objective: This study compared the effects of a commercial VLCKD (...