Endocrine Abstracts

Background: The water deprivation test serves as a key diagnostic test to differentiate between Arginine Vasopressin Deficiency (AVP-D), Arginine Vasopressin Resistance (AVP-R), and Psychogenic Polydipsia (PP) in patients presenting with symptoms of polydipsia and polyuria, when common causes such as diabetes mellitus have been excluded. This study evaluated the established diagnostic values for serum osmolality, serum sodium, and urine osmolality.Method...

Introduction: In up to 50 percent of Cushing’s disease patients, corticotroph adenomas are not clearly identified on MRI and long-term medical treatment to lower cortisol may be needed. Osilodrostat, which inhibits 11 beta hydroxylase, is effective in normalising urinary free cortisol (UFC). We are the UK’s first centre to use osilodrostat for Cushing’s disease in MRI negative patients.Method: Five patients (one male) with Cushing’s d...

Background: Correct identification of patients with HPA axis dysfunction following trans-sphenoidal pituitary surgery is important. Our centre measures post-operative day 5 0900 h serum cortisol (24 h after the last dose of glucocorticoid) to identify the need for glucocorticoid replacement. This is given if post-operative day 5 0900 h cortisol concentration is <300 nmol/l, until dynamic pituitary function assessment occurs.Methods: Data were reviewe...

Background: Prolonged glucocorticoid (GC) use is associated with significant morbidity and mortality, including the development of glucocorticoid-induced adrenal insufficiency (GI-AI). There is currently no consensus regarding testing or weaning of GCs prescribed for non-endocrine conditions.Aim: To assess the long-term GC weaning practice by endocrinologists in the UK and Southeast Asia.Methods: An anonymous survey was disseminate...