Searchable abstracts of presentations at key conferences in endocrinology

ea0044p88 | Clinical biochemistry | SFEBES2016

Prednisolone and fludrocortisone as once daily treatment following adrenalectomy

Papadopoulou Deborah , Choudhury Sirazum M , Meeran Karim

Mrs SP was a 50-year old patient who presented with typical features of Cushing’s syndrome in 2003 and proceeded to pituitary surgery. Following this she was not cured, and elected to have a bilateral adrenalectomy. Following this, she was initially commenced on hydrocortisone 30 mg daily taken as 15 mg in the morning, 10 mg at noon and 5 mg at 1600 h, and fludrocortisone 100 μg daily. She continued on this for 10 years, but switched her glucocorticoid replacement to...

ea0044p89 | Clinical biochemistry | SFEBES2016

The use of 8-h serum prednisolone concentrations to guide prednisolone dosing in replacement therapy

Papadopoulou Deborah , Choudhury Sirazum M , Meeran Karim , Wernig Florian

We here report the cases of two patients receiving glucocorticoid replacement, whose treatment has been guided by serum prednisolone measurements and whose day curves are presented below. Ms B was a 33-year-old patient who presented 3 years ago with panhypopituitarism following transsphenoidal surgery in 2012, for a sellar mass in a foreign country. She had already commenced 5mg prednisolone daily in addition to DDAVP, levothyroxine and the COCP. Having noticed mild weight gai...

ea0094p130 | Thyroid | SFEBES2023

Radioactive iodine treatment outcomes at imperial college healthcare NHS Trust

Gnanananthan Pairavi , Papadopoulou Deborah , Khan Sairah , Naik Mitesh , Meeran Karim

Background: Before radioiodine (RAI) therapy patients undergo a technetium 99m thyroid uptake scan and anti-thyroid medication is stopped prior to treatment following clinical review with the nuclear medicine team. Once treated, patients are followed up in the post-radioiodine telephone clinic. Thyroid function is checked at 3, 6, 9 and 12 weeks. Levothyroxine is started once the fT4 is <14 pmol/l.Purpose: To assess ...

ea0094p26 | Adrenal and Cardiovascular | SFEBES2023

Withdrawal of glucocorticoid replacement in patients following treatment for Cushing’s: The importance of reassessing the need for long term replacement

Narula Kavita , Lazarus Katharine , Choudhury Sirazum , Papadopoulou Deborah , Tan Tricia , Meeran Karim

Generous glucocorticoid (GC) replacement following pituitary or adrenal surgery for Cushing’s can result in persistent suppression of the pituitary corticotrophs, evidenced by poor short synacthen test (SST) responses. Dose reduction can result in increased fatigue so patients tend to prefer to remain on higher doses. Long-term GC therapy is associated with increased morbidity and mortality. We present two cases where GC therapy was successfully weaned through a gradual t...

ea0094p184 | Adrenal and Cardiovascular | SFEBES2023

Prednisolone replacement therapy is associated with significant weight loss in patients who switch from hydrocortisone with adrenal insufficiency

Lazarus Katharine , Choudhury Sirazum , Narula Kavita , Papadopoulou Deborah , Tan Tricia , Meeran Karim

Background: Adrenal Insufficiency (AI) is a life-threatening disorder caused by dysfunction of the adrenal axis (primary AI) or of the hypothalamic-pituitary-adrenal axis (secondary AI). Both result in glucocorticoid deficiency, requiring life-long replacement, with additional mineralocorticoid replacement required in primary AI. However, accurately reproducing the endogenous circadian and ultradian rhythm of cortisol secretion is challenging. Current Endocrin...

ea0038p352 | Reproduction | SFEBES2015

I.v. and s.c. infusions of kisspeptin-54 stimulate gonadotrophin release similarly in healthy women

Narayanaswamy Shakunthala , Jayasena Channa , Ng Noel , Ratnasabapathy Risheka , Papadopoulou Deborah , Prague Julia , Abbara Ali , Comninos Alexander , Bloom Stephen , Dhillo Waljit

Background: Kisspeptin stimulates hypothalamic GnRH secretion resulting in gonadotrophin release and has the potential as a future therapeutic for infertility. Previous studies have observed that kisspeptin increases LH and to a lesser degree FSH when administered to healthy women, which may limit its therapeutic potential. However, studies in women with hypothalamic amenorrhoea show that i.v. infusions of kisspeptin-54 stimulated both LH and FSH equally. Chronic s.c. infusion...

ea0065p373 | Reproductive Endocrinology and Biology | SFEBES2019

Should SHBG be measured in every patient before diagnosing hypogonadotrophic hypogonadism?

Phylactou Maria , Abbara Ali , Eng Pei Chia , Clarke Sophie A. , Papadopoulou Deborah , Izzi-Engbeaya Chioma , Jayasena Channa N , Comninos Alexander N , Tan Tricia , Dhillo Waljit S

Case: A 19-year-old British-Asian man presented with a two-year history of gynaecomastia. He had no other symptoms of hypogonadism. On examination, BMI was 28 kg/m2 and he had post-pubertal-sized testes (20 ml) with normal secondary sexual characteristics. Hypogonadism was confirmed by two morning fasting total testosterone levels of 4.7 and 5.2 (RR 9.2–31.6 nmol/l). Haemoglobin was normal (152 g/l) and serum oestradiol was <100 pmol/l. He had inappropriate...

ea0094p267 | Reproductive Endocrinology | SFEBES2023

Kallmann syndrome with unilateral anosmia

Tsoutsouki Jovanna , N Comninos Alexander , Phylactou Maria , Chia Eng Pei , Patel Bijal , Modi Manish , Young Megan , Papadopoulou Deborah , R Howard Sasha , S Dhillo Waljit , Abbara Ali

Introduction: Kallmann syndrome (KS) is a rare genetic disorder typically due to defective migration of olfactory-axons and GnRH-neurons. KS results in congenital hypogonadotrophic hypogonadism (CHH) typically associated with absent (anosmia) or reduced (microsmia) sense of smell. Unilateral hypoplastic/absent olfactory bulbs on MRI are reported, although disturbance in smell is usually bilateral. Here, we present an unusual case of KS with unilateral anosmia....

ea0099p551 | Reproductive and Developmental Endocrinology | ECE2024

Endocrine responses to kisspeptin in an unusual case of kallmann syndrome with unilateral anosmia

Tsoutsouki Jovanna , N Comninos Alexander , Phylactou Maria , Patel Bijal , Mills Edouard , Young Megan , Yeung Arthur , Koysombat Kanyada , Modi Manish , Papadopoulou Deborah , Howard Sasha , S Dhillo Waljit , Abbara Ali

Introduction: Kallmann syndrome (KS) is a rare condition characterised by congenital hypogonadotropic hypogonadism (CHH), usually due to defective migration of olfactory axons and GnRH-neurons. KS is typically associated with absent (anosmia) or reduced (microsmia) sense of smell. Unilaterally hypoplastic or absent olfactory bulbs on MRI are reported, although disturbance in smell is usually bilateral. Kisspeptin is a potent stimulator of hypothalamic GnRH-neurons, and endocri...