Abstract Search

ea0030p47 | (1) | BSPED2012

Beckwith-Wiedemann syndrome with paternally inherited duplication of chromosome 11p and a deletion of the long arm of chromosome 11

Arya Ved Bhushan , Papadopoulou Maria , Senniappan Senthil , Hussain Khalid

Introduction: Beckwith-Wiedemann syndrome (BWS) is characterized by hyperinsulinaemic hypoglycaemia (HH), overgrowth, tumour predisposition and congenital malformations. Commonly, BWS is caused by epigenetic or genomic alterations, which disrupt genes in one or both of the two imprinted domains on chromosome 11p15.5. Rarely (~1%), paternally inherited duplications of 11p15 can result in BWS phenotype. We describe the first case of BWS associated with a paternally inherited dup...

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ea0059p124 | Neuroendocrinology and pituitary | SFEBES2018

A single bolus of the novel kisspeptin analogue, MVT-602, induces a prolonged LH surge compared to kisspeptin-54 during the follicular phase in healthy women

Clarke Sophie A , Abbara Ali , Chia Eng Pei , Phylactou Maria , Papadopoulou Deborah , Muralidhara Koteshwara , Mills Edouard , Jones Sophie , Pratibha Machenahalli C , Chia Germaine , Yang Lisa , Izzi-Engbeaya Chioma , Sykes Mark , Prague Julia K , Comninos Alexander N , Dhillo Waljit S

Background: Kisspeptin-54 (KP54) stimulates hypothalamic GnRH release. The kisspeptin analogue, MVT-602, has a longer half-life (t1/2108min) than KP54 (t1/228mins). MVT-602 potently stimulates gonadotrophin release in men. We sought to determine for the first time the effect of MVT-602 on gonadotrophin release in healthy women.Methods: A two-phase dose-finding study was carried out in 9 healthy women, 1835 yrs with regular men...

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Endocrine Abstracts

Beckwith-Wiedemann syndrome with paternally inherited duplication of chromosome 11p and a deletion of the long arm of chromosome 11

A single bolus of the novel kisspeptin analogue, MVT-602, induces a prolonged LH surge compared to kisspeptin-54 during the follicular phase in healthy women

BiosciAbstracts