Searchable abstracts of presentations at key conferences in endocrinology

ea0041gp237 | Thyroid Cancer (1) | ECE2016

The origin of patients with inherited medullary thyroid cancer, who are carriers of the rare exon 8 mutation (G533C) of the RET gene in Greece

Saltiki Katerina , Anagnostou Elli , Angelopoulou Anastasia , Kouki Sofia , Apostolakis Michail , Sarika Lida , Papathoma Alexandra , Alevizaki Maria

Introduction: Mutations in the ret gene are responsible for the transmission of inherited medullary thyroid cancer (MTC). In recent years a high prevalence of the ‘rare’ exon 8 mutation (G533C) has been found in patients with inherited MTC in Greece. The aim of this study was to record with more detail the place of origin of these families in the country.Design: We analysed the details of 44 patients belonging to 22 families who were c...

ea0035p1102 | Thyroid Cancer | ECE2014

Familial medullary thyroid carcinomas: RET mutation in exon 8 is associated with better prognosis but increased risk for other malignancies

Saltiki Katerina , Rentziou Gianna , Angelopoulou Anastasia , Apostolakis Michael , Papathoma Alexandra , Alevizaki Maria

Objectives: In familial MTC there is genotype-phenotype correlation. The phenotype and clinical outcome in exon8 (G533C) carriers has not been well established.Methods: 95 patients operated for familial MTC (27.2% males) were followed for 0.9–30 years (mean 8.0, median 5.5 years). 45.3% (n=43) were exon8 carriers (exon8MTC) and the remaning were non-exon8MTCs (n=52, exons 10, 11, 13, 14, and 16). Pre-, postoperative calcitonin, ext...