Searchable abstracts of presentations at key conferences in endocrinology

ea0056p673 | Nuclear receptors and Signal transduction | ECE2018

Vitamin D abolishes the dexamethasone-induced apoptosis in acute myeloid leukemia cells via regulation of Notch signaling

Karapanagioti Angeliki G , Nasiri-Ansari Narjes , Angelousi Anna , Kalotychou Vasiliki , Papavasilliou Athanasios G , Kassi Eva

Introduction: Glucocorticoids are used for treatment of various hematological malignancies such as Acute Myeloid Leukemia (AML). Glucocorticoids are known to induce apoptosis by regulating the expression of key anti- or pro-apoptotic genes. Vitamin D induces apoptosis and cell cycle arrest in various types of cancer cells. Despite recent advances in treatment of AML, the poor response rate to therapy remains a big challenge.Therefore, discovering new factors that can affect th...