Searchable abstracts of presentations at key conferences in endocrinology

ea0022oc1.1 | Diabetes and obesity | ECE2010

Role of newly identified immunosuppressive NK cells in autoimmunity

Ehlers Margret , Papewalis Claudia , Jacobs Benedikt , Thiel Annette , Schinner Sven , Willenberg Holger S , Scherbaum Werner A , Schott Matthias

Most recently, a completely new subset of NK cells with immunosuppressive functions has been identified. These cells are able to downregulate conventional NK cells in a PD1-ligand dependent manner and are, therefore, responsible for tumor outgrowth.The aim of our present study was to investigate the role of this new NK subset in autoimmunity. For this purpose, we used two independent mouse models. In the NOD mice, we found a large increase of suppressive...

ea0016p59 | Adrenal | ECE2008

Evidence for the involvement of endothelial cell products in adrenal CITED2 expression

Haase Matthias , Ansurudeen Ishrath , Schinner Sven , Paramonova Iryna , Schott Matthias , Papewalis Claudia , Krug Alexander , Scherbaum Werner A , Willenberg Holger S

The mechanisms that lead to tumor formation of and aldosterone secretion by zona glomerulosa cells in primary aldosteronism are not known. Recently, endothelial cell-derived factors have been characterized that control the release of aldosterone by adrenocortical cells. In addition, we started to characterize the regulation of CITED2, a CBP/p300 interacting transactivator with ED-rich tail 2. Earlier, it was shown in mice that absence of CITED2 leads to adrenal agenesis. Since...