Endocrine Abstracts

Introduction: Data on the role of endogenous sex steroids in cerebrovascular disease is sparse. Our aim was to investigate the clinical relevance of circulating sex steroids in a postmenopausal acute stroke population and search for associations with disease severity and short-term outcome.Patients and methods: We prospectively studied 302 postmenopausal female patients hospitalized for an acute stroke in two tertiary hospitals, during a time period of 2...

Introduction: Several studies have examined the association of the common PvuII polymorphism of the estrogen receptor alpha (ERα) gene with the risk of stroke. Data linking the polymorphism with the severity and outcome of cerebrovascular disease is lacking. We looked for possible associations of the PvuII polymorphism with stroke severity and short-term prognosis in a cohort of female stroke patients.Patients-Methods: We studied 302 postmenopausal ...

Introduction: DHEAS is among the most abundant sex steroid products of the adrenal gland. DHEAS levels have been repeatedly associated with cardiovascular disease, but data concerning cerebrovascular disease, especially in women, is lacking. In this study, we aimed to investigate the role of DHEAS in a female population suffering an acute stroke.Patients and methods: We studied 302 consecutive female patients presenting with an acute stroke hospitalized ...

Introduction: Adrenocorticotropin (ACTH)-independent macronodular adrenal hyperplasia (AIMAH) is a rare cause of Cushing’s syndrome, commonly involving the aberrant expression of several membrane-bound adrenal receptors. Recent studies have investigated whether the latter is also implicated in the renin-independent aldosterone secretion of hyperaldosteronism cases.Case report: A 35-year-old man presented to our department for evaluation of new-onset...

Introduction: Autonomous aldosterone secretion (AAS) is present in approximately 10% of hypertensives. Adrenal incidentalomas (AI) can be found in up to 19% of hypertensive individuals. However, data on the incidence of AAS in hypertensive patients with AI is scarce. Our aim was to evaluate the adrenal aldosterone secretory profile in patients with adrenal adenomas with and without arterial hypertension.Patients and methods: We investigated 72 normotensi...

Introduction: Patients with adrenal adenomas appear to exhibit an appreciable prevalence of autonomous aldosterone secretion (AAS). Our aim was to evaluate the anti-hypertensive effect of targeted therapy with mineralocorticoid receptor (MR) antagonists in AAS patients.Patients and methods: We studied 60 hypertensive patients, 21 males and 39 females, harboring an adrenal adenoma with AAS. All patients were receiving combination of anti-hypertensive trea...