Searchable abstracts of presentations at key conferences in endocrinology

ea0041ep473 | Diabetes (to include epidemiology, pathophysiology) | ECE2016

Insulin secretion several years after type 1 diabetes diagnosis: case reports

Margarida Monteiro Ana , Paredes Silvia , Alves Marta

Introduction: Currently, type 1 diabetes (T1D) is defined by the autoimmune destruction of the pancreatic β cells that culminates in dependence on exogenous insulin, typically 1–3 years after diagnosis. This ability to maintain a residual function of pancreatic β cells is, however, heterogeneous, appearing to be worst if the disease is early diagnosed. Recently, it was demonstrated that many type 1 diabetic patients produce small amounts of insulin decades after...

ea0056p385 | Diabetes (to include epidemiology, pathophysiology) | ECE2018

Gestational diabetes – association of lipid profile in pregnancy with post-partum dysglycemia

Paredes Silvia , Fernandes Aline , Pereira Maria Lopes

Introduction: Lipid profile characterization in women with gestational diabetes mellitus (GDM) and its impact on post-partum dysglycemia remains to elucidate. The aim of this study was to evaluate lipid profile in women with GDM during pregnancy and 8 weeks after and to study its correlation with glycemic control.Methods: This study was carried out in a central hospital in Portugal. All women with GDM diagnosed from January/2014 to December/2015 were enr...

ea0056p721 | Clinical case reports - Pituitary/Adrenal | ECE2018

Late onset adrenocorticotrope deficiency in combined pituitary hormone deficiency caused by a mutation of the PROP1 gene

Paredes Silvia , Marques Olinda , Alves Marta

Introduction: PROP1-related combined pituitary hormone deficiency (CPHD) is associated with deficiencies of growth hormone (GH); thyroid-stimulating hormone (TSH); gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH); prolactin (PRL); and occasionally adrenocorticotropic hormone (ACTH).Clinical case: We report a clinical case of a progressive CPHD in a man presenting with first symptoms of hypocortisolism at the age of 75 years....

ea0090ep1114 | Late Breaking | ECE2023

Wernicke Encephalopathy Due To Bariatric Surgery: Recounting A Case Report

V. de Assuncao Guilherme , Paredes Silvia , Cardoso Helena

Introduction: Wernicke Encephalopathy (WE) is an acute neurologic disorder caused by thiamine deficiency. It is characterized by the classic triad of encephalopathy, gait ataxia and oculomotor dysfunction. It occurs in the setting of poor nutrition caused by lack of dietary intake or malabsorption. Since both of them can happen in patients that underwent bariatric surgery it is of utmost importance to prevent, recognize and treat this severe complication.<p class="abstext"...

ea0070aep537 | Endocrine-related Cancer | ECE2020

Pheochromocytoma due to TMEM127 mutation – the importance of genetic test for clinical decision

Paredes Silvia , Lopes Sara , Torres Isabel , Alves Marta

Background: Catecholamine-secreting tumors that arise from chromaffin cells of the adrenal medulla and the sympathetic ganglia are respectively referred to as pheochromocytomas and paragangliomas. The classic triad of symptoms in patients with pheochromocytoma (PHEO)consists of episodic headache, sweating, and tachycardia. Approximately one-half have paroxysmal hypertension; the rest have either primary hypertension or normal blood pressure. Clinicians should always consider P...

ea0056p879 | Pituitary - Clinical | ECE2018

Radiotherapy for pituitary adenomas – safety and efficacy analysis

Paredes Silvia , Ramos Rui , Almeida Rui , Marques Olinda

Introduction: Radiotherapy (RT) has been proven to be effective in controlling hormone production and tumor growth in pituitary adenomas (PA). Still, RT adverse effects had turned it an unattractive choice of treatment. The aim of this study was to evaluate the efficacy and safety of RT for patients with PA.Methods: We conducted a retrospective study of patients treated in our center, a central hospital, since 1998. Thirty-three patients were included, 6...

ea0063p880 | Adrenal and Neuroendocrine Tumours 3 | ECE2019

Cardiovascular and metabolic risk factors in children and adolescents with congenital adrenal hyperplasia due to 21-hydroxylase deficiency

Paredes Silvia , Alves Marta , Carvalho Fabia , Gomes Maria Miguel , Martins Sofia , Marques Olinda , Antunes Ana

Background: Congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency is associated with an increased cardiometabolic risk in adult life. Nevertheless, data regarding pediatric age is scarce. We aimed to evaluate cardiometabolic risk factors in patients with CAH due to 21-hydroxylase deficiency in pediatric age.Methods: We reviewed the clinical records of patients with CAH evaluated in a Pediatric Endocrinology Unit in a central hospital. Pat...

ea0041ep781 | Obesity | ECE2016

Bariatric surgery: a health economic perspective of the prescription costs

Paredes Silvia , Pereira Maria Lopes , Fernandes Aline , Manso Fernando , da Costa Maia , Marques Olinda , Alves Marta

Introduction: The economic burden of obesity on healthcare systems is increasing. Bariatric surgery leads to considerable weight loss and health improvement. However, this surgery is costly and doubts about its affordability have been raised. Few studies have assessed outcomes such as drug use and costs after bariatric surgery. The aim of this study was to evaluate drug consumption and costs before and after bariatric surgery.Methods: Retrospectively, da...

ea0056p313 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2018

Metabolic syndrome and triglyceride-rich lipoproteins

Paredes Silvia , Fonseca Liliana , Carlos Oliveira Jose , Ramos Helena , Palma Isabel

Introduction: Hypertriglyceridemia, a cardinal feature of metabolic syndrome (MS), is associated with cardiovascular disease and abnormal metabolism of apolipoproteins which may form the basis for this relationship. The aim of this study is to evaluate triglyceride-rich lipoproteins profile in MS patients.Material and methods: A retrospective study was performed, including patients evaluated in a tertiary hospital. Patients with thyroid dysfunction, neop...

ea0056p316 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2018

Identifying metabolic unhealthy obesity using the product of triglycerides and glucose

Fonseca Liliana , Paredes Silvia , Carlos Olivera Jose , Ramos Helena , Palma Isabel

Introduction: There are significant physiologically and clinically differences in profiles between metabolic healthy and metabolic unhealthy obese individuals. Several markers are on study in order to better characterize the metabolic profile of metabolic unhealthy obese individuals. The aim of this work was to determine whether the triglycerides/glucose (TyG) index may be a valuable marker for identifying metabolically unhealthy obesity.Methodology: Met...