Endocrine Abstracts

Familial hypocalciuric hypercalcaemia (FHH) usually manifests with mild asymptomatic hypercalcaemia. Presentations with severe hypercalcaemia are uncommon and may be mistakenly assumed to be primary hyperparathyroidism (PHPT) unless detailed testing is undertaken on all cases of hypercalcaemia. We present 4 cases of FHH presenting with severe hypercalcalcaemia, corrected serum calcium (coCalcium) > 3 mmol/l. Three cases were initially admitted to hospital as medical emergencie...

79 year old gentleman was reviewed as new patient in the Endocrine clinic. He was diagnosed with Pituitary Apoplexy of a Non-functioning Adenoma in 1998. He was under surveillance and the tumour remained relatively stable with no complications until 2008.Surgical history: There was a gradual increase in the size of the adenoma over 5 years. He underwent Transphenoidal adenectomy in Feb 2014 as the tumour was draped over the optic chiasm. Intra-operativel...

Background: We present a rare diagnosis of a patient presenting with Takotsubo cardiomyopathy and pituitary apoplexy. The case highlights the difficulty in management of a cardiac event with bleeding risk in a patient with these associated diagnoses.Case report: An 85-year-old woman was admitted to hospital with a severe frontal headache that woke her from sleep. She described chest pain associated with breathlessness later and was mildly confused. Sadly...

The milk – alkali syndrome was well known in the pre-proton pump inhibitor era when remedies for peptic ulcer included a large amount of calcium and sodium bicarbonate resulting in hypercalcaemia, metabolic alkalosis and often acute kidney injury. In a study done from 1998 to 2003, milk alkali syndrome was the cause of hypercalcaemia in 8.8 percent of the cases which is a significant percentage, so awareness about it is important.<p class="abste...

Moyamoya disease is a progressive chronic neurological disease due to multiple narrowing of the carotid arteries. It can be seen in association with atherosclerosis, vasculitis, haematological conditions, connective tissue disease, neurocutaneous syndromes and certain autoimmune diseases. Very few cases have been reported in association with Graves disease and the majority being in the East Asian population. We present a rare case of this association in a young C...

The milk – alkali syndrome was well known in the pre-proton pump inhibitor era when remedies for peptic ulcer included a large amount of calcium and sodium bicarbonate resulting in hypercalcaemia, metabolic alkalosis and often acute kidney injury. In a study done from 1998 to 2003, milk alkali syndrome was the cause of hypercalcaemia in 8.8 percent of the cases which is a significant percentage, so awareness about it is important.<p class="abste...

Moyamoya disease is a progressive chronic neurological disease due to multiple narrowing of the carotid arteries. It can be seen in association with atherosclerosis, vasculitis, haematological conditions, connective tissue disease, neurocutaneous syndromes and certain autoimmune diseases. Very few cases have been reported in association with Graves disease and the majority being in the East Asian population. We present a rare case of this association in a young C...

Section 1: Case history: This 41 year old lady was seen in the Endocrine clinic with an 8 year history of worsening hypertension, obesity and Type 2 diabetes. She had no conditions known to cause physiological hypercortisolism, no exogenous steroid use and had clear physical features of Cushing’s syndrome.Section 2: Investigations: Investigations confirmed Cushing’s syndrome with two elevated urinary free cortisol assessments (UFC) (934 and 906...

Hyponatremia is the commonest electrolyte abnormality presenting to Medical Admissions and when acute, severe and symptomatic, is associated with high mortality. The syndrome of inappropriate antidiuretic hormone secretion (SIADH) is the most common underlying disorder in hospitalised patients with euvolaemic hyponatraemia and is a complication of many clinical conditions and drug therapies.We discuss the cases of two patients...

Hyponatremia is the commonest electrolyte abnormality presenting to Medical Admissions and when acute, severe and symptomatic, is associated with high mortality. The syndrome of inappropriate antidiuretic hormone secretion (SIADH) is the most common underlying disorder in hospitalised patients with euvolaemic hyponatraemia and is a complication of many clinical conditions and drug therapies.We discuss the cases of two patients...