Searchable abstracts of presentations at key conferences in endocrinology

ea0039ep118 | Pituitary and growth | BSPED2015

Mosaic form of Turner’s can be associated with normal stature and spontaneous puberty: a case report.

Park J , Losa I

Background: Turner’s syndrome is the most common sex chromosome abnormality in females resulting from a 45,X cell line. A mosaic chromosomal complement (e.g. 45,X/46,XX) is detectable in over half of all patients with Turner’s. Characteristically girls with Turner syndrome have a short stature attributable to the presence of SHOX (short stature homeobox-containing gene on the X chromosome) gene. Most affected women have no pubertal development and primary am...

ea0029p442 | Clinical case reports - Thyroid/Others | ICEECE2012

A case of pneumomediastinum and tracheomalasia in thyroid storm with longstanding goiter

Lee K. , Park C.

Tracheomalasia is extremely rare condition in Graves’ disease and may result in pneumomediastium with fistular formation from longstanding compression by a large goiter. There is no report that Graves’ disease combined with tracheomalasia and pneumomediastinum. A 24-year-old woman presented with abdominal pain, diarrhea and fever. On physical examination, a large goiter was detected on her anterior neck. Computed tomography of chest showed large amount of air in ante...

ea0029p609 | Diabetes | ICEECE2012

Resolution of type 2 diabetes following IFN-α therapy for chronic hepatitis C

Kim D. , Park J.

We report on a patient whose type 2 diabetes resolved following interferon-α (IFN-α) therapy for hepatitis C virus (HCV). A 57-years-old man, presented with fatigue, polyuria and polydipsia. He was newly diagnosed with type 2 diabetes. During the hospital day, he was also diagnosed with chronic hepatitis. Serological studies for chronic hepatitis demonstrated presence of hepatitis C, type 2a/2c genotype. He was started on subcutaneous insulin and IFN-α. After 24...

ea0029p1158 | Nuclear receptors and Signal transduction | ICEECE2012

Hypoxia-induced estrogen receptor alpha activation is mediated by both the MAPK and PI3K phosphorylation pathways

Park J. , Lee Y.

The estrogen receptor (ER) plays an important role in breast cancer development and progression. Hypoxia was shown to modulate the level of ERα expression and induce ligand-independent transcriptional activation of ERα, which may be intimately associated with the biology of breast carcinomas. Given that phosphorylation affects the transcriptional activity and stabilization of ERα, we examined the changes in phosphorylation of ERα under hypoxic conditions. H...

ea0037ep843 | Thyroid cancer | ECE2015

Clinical significance of BRAF (V600E) mutation in papillary thyroid microcarcinoma

Park Jisun , Shim Hye Kyung

Objective: The purpose of this retrospective study was to correlate BRAF (V600E) mutation with clinicopathological characteristics in papillary thyroid microcarcinoma (PTMC).Methods: We reviewed the clinical records of patients who were operated for a papillary thyroid microcarcinoma (PTMC) between May 2011 and October 2012 in Inje University Haeundae Paik Hospital. We investigated the prevalence of the BRAF (V600E) mutation, and relations between the pr...

ea0029p237 | Calcium & Vitamin D metabolism | ICEECE2012

The daily calcium intake is associated with sarcopenia in older, non-obese koreans: the fourth korea national health an nutrition examination surveys (KNHANES IV) 2009

Park C. , Rhee E. , Oh K. , Park S. , Park S. , Kim S. , Lee W. , Seo M.

Backgroud: The association with daily calcium intake and sarcopenia has not been well established.Objective: The objective was to assess the associate of daily calcium intake and sarcopenia.Methods: We analysed the fourth Korea National Health and Nutrition Examination Survey (KNHANES) in old adult (over 50 years), conducted in 2009. A total of 1964 non-obese (body mass index (BMI) <25 kg/m2) old adults (871 men and ...

ea0029p535 | Diabetes | ICEECE2012

The Association of the severity of nonalcoholic fatty liver disease with development of type 2 diabetes: A 4-year longitudinal study

Choi J. , Bae J. , Park S. , Rhee E. , Park C. , Oh K. , Park S. , Kim S. , Lee W.

Aims: Nonalcoholic fatty liver disease (NAFLD) is reported to contribute to the development of type 2 diabetes, but it is largely unknown whether such a relationship between NAFLD and incident diabetes relates to the severity of NAFLD or it is independent. We aimed to evaluate the association of the severity of NAFLD with development of type 2 diabetes in a retrospective cohort of Korean subjects.Methods: This study included 7,849 individuals without dia...

ea0081p70 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Cause of Death for Patients with Diabetes Mellitus in Korea: Multicenter study

Moon Hyeyeon , Park Mi Kyoung , Suh Sunghwan

Background: In Republic of Korea, prevalence of type 2 diabetes mellitus (T2DM) has increased substantially in recent decades, but there are no reliable estimates of the excess mortality currently associated with diabetes.Methods: We analyzed all subjects were T2DM patients over the age of 30 whose death certificates were issued at three hospitals in the Busan metropolitan area from 2010 to 2014. The causes of death were retrospectively determined based ...

ea0049gp169 | Obesity | ECE2017

Blood mercury concentration in relation to overweight or obese among Korean children and adolescents: KNHANES 2009–2013

Park Kyung Hee , Kim Jeong-Hyeon

Background: Harmful effects of mercury on cardiovascular disease have been suggested in many epidemiologic studies. However, reports on harmful effect of mercury in relation to overweight or obesity have shown inconsistent findings.Methods: A total of 1577 children and adolescents (10–18 years of age) from the Korean National Health and Nutrition Examination Survey (KNHANES) 2009–2013. Overweight or obese group was defined as over the 85th perc...

ea0041ep639 | Endocrine tumours and neoplasia | ECE2016

Effects of genetically engineered human neural stem cells expressing cytosine deaminase and interferon-beta on the growth of lymph node metastatic colorectal adenocarcinoma

Park Geon-Tae , Choi Kyung-Chul

Genetically engineered stem cells may be advantageous for gene therapy against various human cancers due to their inherent tumor-tropic properties. In this study, we employed human neural stem cells (HB1.F3; hNSCs) transduced with genes expressing Escherichia coli cytosine deaminase (HB1.F3.CD) and human interferon-beta (HB1.F3.CD.IFN-β) as a treatment strategy for human lymph node metastatic colorectal cancer. CD can convert the prodrug 5-fluorocytosine (5-FC) to its act...