Searchable abstracts of presentations at key conferences in endocrinology

ea0028p242 | Pituitary | SFEBES2012

Development of a platform technology to generate long-acting protein therapeutics

Parry Heather , Thorpe Alice , Wilkinson Ian , Pradnanhanga Sarbendra , Sayers Jon , Artymiuk Peter , Ross Richard

Background: The development of recombinant biologics such as interferon, insulin and Growth Hormone (GH) has had a major impact on the management of diseases including hepatitis, diabetes and GH-deficiency. However, most biologics undergo rapid renal filtration and proteolytic degradation, necessitating frequent dosing regimens. Pegylation can successfully delay clearance but has several drawbacks including potential toxicity, expense and reduced activity. There is therefore n...