Searchable abstracts of presentations at key conferences in endocrinology

ea0035p409 | Diabetes complications | ECE2014

Associated study of polymorphic variants in the gene for superoxide dysmutase (Mn SOD) and different types of diabetes mellitus

Pashkunova Sylvia , Ivanov Valentin , Savov Alexey

Superoxid dysmutase (SOD) is a key antioxidant enzyme engaged in detoxication of superoxide radicals. Ala/Val substitution in Mn SOD leads to a change in the effectiveness of the action of the enzyme. This polymorphism we analyzed among several groups patients with diabetes and we compared with control group of healthy volunteers. It is proved an association connection of tracked marker in some of the groups of patients with diabetes compared to the rest population sample. Suc...

ea0073oc15.6 | Oral Communications 15: Late Breaking | ECE2021

Genetic polymorphism (IP-10/CXCL10) and diabetes mellitus type 1

Pashkunova Sylvia , Daneva Teodora , Vassilev Dimitar , Kostadinov Nikolay , Tsonev Stefan , Vangelova Joana , Vitanova Detelina

IntroductionThe development of Diabetes mellitus type 1 (DMT1) is considered as an autoimmune pro-inflammatory process. Human enteroviruses are thought to be also a cause. These viruses influence beta cells and cause expression of immunological factors. The affected cells destroy the related beta cells. The aim of the work is to study the genetic polymorphisms in IP-10/CXCL10 and its receptors CXCR3 and TLR4 in order to predict expression of DMT1.<p ...