Endocrine Abstracts

Background: A moderately high fructose diet fed to rat dams shifts the secondary sex ratio in the litters towards males. These dams, as well as diabetic pregnant mice, have elevated plasma glucose. Hence, high uterine fluid glucose or a hormone that may mark high glucose, may result in preferential selection of Y-bearing sperm at the point of fertilisation through effects of glucose on sperm motility. In this study, we assessed sperm motility after incubation in media with/wit...

Background: Management of pituitary conditions is notoriously difficult and patients often experience high levels of distress which are often not addressed by health professionals. As a result, pituitary conditions have been found to have a large negative impact on quality of life. The aims of this study were 1) to identify the psychosocial symptoms associated with pituitary conditions, and 2) to identify any differences in symptomatology...

Background: Pituitary conditions have been found to have a significant impact on quality of life. As such it is important that patients have access to support services to ensure their ongoing physical and psychological needs are met. The aim of this study was to explore the experiences of patients with pituitary conditions who are members of the Pituitary Foundation to better understand how the Foundation supports their needs.<p class...

We present the case of a 32 year old woman presenting to her GP with right lower leg pain. This pain was worse at night, but responded to simple analgesia. She was initially diagnosed with arthritis but the leg pain worsened and became bilateral. She had no other significant past medical history with no history of fevers, trauma, fractures or dental problems. She had no relevant family, social or medication history.On examination, ...

Background: Management of pituitary conditions is notoriously difficult and patients often experience high levels of distress which are often not addressed by health professionals. As a result, pituitary conditions have been found to have a large negative impact on quality of life. The aims of this study were 1) to identify the psychosocial symptoms associated with pituitary conditions, and 2) to identify any differences in symptomatology...

Background: Pituitary conditions have been found to have a significant impact on quality of life. As such it is important that patients have access to support services to ensure their ongoing physical and psychological needs are met. The aim of this study was to explore the experiences of patients with pituitary conditions who are members of the Pituitary Foundation to better understand how the Foundation supports their needs.<p class...

We present the case of a 32 year old woman presenting to her GP with right lower leg pain. This pain was worse at night, but responded to simple analgesia. She was initially diagnosed with arthritis but the leg pain worsened and became bilateral. She had no other significant past medical history with no history of fevers, trauma, fractures or dental problems. She had no relevant family, social or medication history.On examination, ...

Background: Endocrinopathic laminitis is a painful equine condition that may cause persistent lameness warranting euthanasia. Hypoadiponectinemia and insulin dysregulation (ID, manifesting as hyperinsulinemia, tissue insulin resistance (IR), and/or excessive insulin responses to non-structural carbohydrates) are independently associated with increased laminitis risk, although underlying mechanisms remain unclear.Methods: This study aimed to investigate t...

A 63-year-old phenotypic male presented with absent testis and enlarged adrenal glands. He had attended the urology clinic for persistent microscopic haematuria. He was found to have an empty scrotum and hypospadias. The patient recalled having genital surgery in childhood but could not recall any endocrine assessment. He was taller than his peers in early childhood but stopped growing after age 13 years. He described himself as ‘potent’. He was unmarried and did not...

Background: Although hypocalcemia is common post thyroidectomy, no national guidelines pertain to its management.Long-term treatment with calcium and vitamin D replacement predispose patients to nephrocalcinosis and should be avoided in the absence of a clear indication.Aim: To identify the incidence and management of post-operative hypocalcemia following thyroidectomy in a UK teaching hospital with view to formulating management g...