Searchable abstracts of presentations at key conferences in endocrinology

ea0012oc2 | Young Endocrinologist prize session | SFE2006

Combinatorial signalling and gene transcription in neuroendocrine cells: does PACAP potentiate hormone-dependent gene transcription?

Monger JK , Patel MV , Jonas KC , Fowkes RC

The neuropeptide PACAP regulates numerous endocrine functions such as growth, metabolism and reproduction. In pituitary gonadotrophs, PACAP acts as a potent stimulator of gonadotrophin gene transcription and secretion, and potentiates the stimulatory effects of GnRH. We have examined the combinatorial effects of PACAP with GnRH or other activators of GnRH-signalling pathways in mouse αT3-1 gonadotroph and rat PC12 phaeochromocytoma cells. αT3-1 cells transiently tran...