Searchable abstracts of presentations at key conferences in endocrinology

ea0090p419 | Pituitary and Neuroendocrinology | ECE2023

Reference intervals for soluble alpha klotho and the impact of biological variables

Ribeiro de Oliveira Longo Schweizer Junia , Schilbach Katharina , Haenelt Michael , Pauline Gagliardo Anica , Peters Anette , Thorand Barbara , Stormann Sylvere , Schopohl Jochen , Bidlingmaier Martin

Background: Alpha klotho is a transmembrane protein that regulates calcium metabolism. Its soluble portion has been linked to endocrine functions. We have recently shown high concentrations of serum soluble alpha klotho (sαKL) in active acromegaly. There is limited information about regulation of sαKL secretion. We aimed to gain insight about sαKL as a potential biomarker for H-related diseases.Methods: SαKL was measured by ELISA (IBL...

ea0099p132 | Pituitary and Neuroendocrinology | ECE2024

Is urine sαkl a potential biomarker in acromegaly?

Pauline Gagliardo Anica , Haenelt Michael , Ribeiro de Oliveira Longo Schweizer Junia , Thorsteinsdottir Jun , Teupser Daniel , Schopohl Jochen , Stormann Sylvere , Bidlingmaier Martin , Schilbach Katharina

Background: Soluble alpha klotho (sαKL) is a peptide hormone, that has been shown to be elevated in serum of patients with uncontrolled acromegaly. One early pilot study suggested that sαKL is also detectable in urine from patients with acromegaly, and significantly drops after surgery. Notably, in this study, urine sαKL concentrations were undetectable in the control group, and fell consistently below the detection limit of the ELISA in postoperative patients i...