Searchable abstracts of presentations at key conferences in endocrinology

ea0070ep13 | Adrenal and Cardiovascular Endocrinology | ECE2020

Distinct clinical course of neuroendocrine tumors presenting ectopic ACTH tissue expression and secretion

Oszywa Michalina , Borowczyk Martyna , Szczepanek-Parulska Ewelina , Gut Paweł , Ruchała Marek

Two female patients, A – 61-year-old, B – 68-year-old, were admitted to hospital with symptoms of hypercortisolemia. Both of them were diagnosed with neuroendocrine tumor (NET), patient A with pancreatic NET G3 (Ki67 – 30%), and patient B with a disease with a probable primary origin in lungs - NET G2 (Ki67 - 15%). Both women had metastases to the liver. While laboratory results were similar in both cases (high level of cortisol – up to 1750 nmol/l and ...

ea0070aep30 | Adrenal and Cardiovascular Endocrinology | ECE2020

Excess glucocorticoid activity may suppress tumor immune activity in adrenocortical carcinoma

Greenstein Andrew , Amir Habra Mouhammed , Mura Marzena , Biernat Paweł , Piatek Marek J , Grauer Andreas , Peacock Shepherd Stacie

Introduction: Excess glucocorticoid (GC) activity has been implicated in the pathophysiology of multiple cancer types. For instance, approximately half of adrenocortical carcinoma (ACC) patients exhibit excess GC (GC+). This provides a unique opportunity to study correlates of GC activity, such as a possible suppression of tumor immune response and immune checkpoint inhibitor (ICI) efficacy due to the broad immunosuppressive effects of GC. ACC multi-omics data can be used ...

ea0049ep48 | Adrenal cortex (to include Cushing's) | ECE2017

Late night salivary cortisol measurement may help in excluding Cushing’s syndrome in patients with chronic kidney disease

Ambroziak Urszula , Kondracka Agnieszka , Rojek-Trębicka Jadwiga , Gajkowski Paweł , Stańczyk Agnieszka , Stępor Malwina , Bednarczuk Tomasz

Objective: The diagnosis of Cushing’s syndrome may be challenging, especially in cases of patients with chronic kidney disease (CKD).Aim: The assessment of late night salivary cortisol concentration, serum and salivary concentration in overnight dexamethasone suppression test in patients with CKD stage III–V and a control group.Patients and methods: 37 patients mean age 66±12 (M=13) with CKD stage III–V...

ea0049oc9.3 | Thyroid Disease 2 | ECE2017

How much of the genetic predisposition to Hashimoto’s thyroiditis can be explained by genes commonly associated with the disease?

Skalniak Anna , Jabrocka-Hybel Agata , Piętkowski Jakub , Turek-Jabrocka Renata , Pach Dorota , Ludwig-Gałęzowska Agnieszka , Machlowska Julita , Kapusta Przemysław , Wołkow Paweł , Hubalewska-Dydejczyk Alicja

Background: Hashimoto’s thyroiditis (HT) is a common autoimmune disorder of the thyroid (AITD) which affects about 1–2% of the European population. The disease often clusters in families, which is why many attempts have been undertaken to find the genetic background that would underly the predisposition to HT. In contrast to another AITD - Graves’ disease, results of genetic analyses have been ambiguous and have failed to find a major genetic locus that would be...