Endocrine Abstracts

Two female patients, A – 61-year-old, B – 68-year-old, were admitted to hospital with symptoms of hypercortisolemia. Both of them were diagnosed with neuroendocrine tumor (NET), patient A with pancreatic NET G3 (Ki67 – 30%), and patient B with a disease with a probable primary origin in lungs - NET G2 (Ki67 - 15%). Both women had metastases to the liver. While laboratory results were similar in both cases (high level of cortisol – up to 1750 nmol/l and ...

Introduction: Excess glucocorticoid (GC) activity has been implicated in the pathophysiology of multiple cancer types. For instance, approximately half of adrenocortical carcinoma (ACC) patients exhibit excess GC (GC+). This provides a unique opportunity to study correlates of GC activity, such as a possible suppression of tumor immune response and immune checkpoint inhibitor (ICI) efficacy due to the broad immunosuppressive effects of GC. ACC multi-omics data can be used ...

Objective: The diagnosis of Cushing’s syndrome may be challenging, especially in cases of patients with chronic kidney disease (CKD).Aim: The assessment of late night salivary cortisol concentration, serum and salivary concentration in overnight dexamethasone suppression test in patients with CKD stage III–V and a control group.Patients and methods: 37 patients mean age 66±12 (M=13) with CKD stage III–V...

Background: Hashimoto’s thyroiditis (HT) is a common autoimmune disorder of the thyroid (AITD) which affects about 1–2% of the European population. The disease often clusters in families, which is why many attempts have been undertaken to find the genetic background that would underly the predisposition to HT. In contrast to another AITD - Graves’ disease, results of genetic analyses have been ambiguous and have failed to find a major genetic locus that would be...