Endocrine Abstracts

Two female patients, A – 61-year-old, B – 68-year-old, were admitted to hospital with symptoms of hypercortisolemia. Both of them were diagnosed with neuroendocrine tumor (NET), patient A with pancreatic NET G3 (Ki67 – 30%), and patient B with a disease with a probable primary origin in lungs - NET G2 (Ki67 - 15%). Both women had metastases to the liver. While laboratory results were similar in both cases (high level of cortisol – up to 1750 nmol/l and ...

Introduction: Polycystic ovary syndrome is complex endocrine disorders, characterized by ovulatory dysfunction, hyperandrogenism and polycystic ovarian morphology. Those are lipid abnormalities, hyperinsulinemia, insulin resistance, impaired glucose metabolism, type 2 diabetes mellitus, metabolic syndrome, hyperandrogenism, oxidative stress and infertility. The visceral adiposity index (VAI) is a reliable marker of adipose tissue abnormalities in women with PCOS. A body shape ...

Introduction: Polycystic ovary syndrome (PCOS) contributes to endocrine and metabolic complications. Cardiovascular disease (CVD) is a leading cause of mortality and morbidity worldwide. Identification of the subpopulations with a higher risk of developing CVD and lipid metabolic disorders is crucial, particularly in PCOS patients.Aim: The aim of this study was to investigate the usefulness of new anthropometric indices such as BAI, VAI, LAP, BRI, ABSI a...

Introduction: Excess glucocorticoid (GC) activity has been implicated in the pathophysiology of multiple cancer types. For instance, approximately half of adrenocortical carcinoma (ACC) patients exhibit excess GC (GC+). This provides a unique opportunity to study correlates of GC activity, such as a possible suppression of tumor immune response and immune checkpoint inhibitor (ICI) efficacy due to the broad immunosuppressive effects of GC. ACC multi-omics data can be used ...

Introduction: Several investigations proved the presence of receptors for androgens, estrogens and progesterone in vocal folds. The most common endocrine disorder causing alterations in the aforementioned hormones concentrations is polycystic ovary syndrome (PCOS), which, according to several studies, can cause voice changes, especially deepening of its timbre. Over last few years, vocal changes accompanying many different disorders have been a subject of research with the use...

Introduction: Saliva is an interesting alternative to blood in clinical evaluation of endocrine function. Certain advantages of saliva collection must be considered, when comparing with conventional blood sampling. Vital arguments are that procedure is easy, non-invasive and stress-free. The studies on correlation between salivary and serum thyroid hormones are scarce and contradictory. The goal of our research was to assess if salivary thyroid hormone levels reflect serum con...

Objective: The diagnosis of Cushing’s syndrome may be challenging, especially in cases of patients with chronic kidney disease (CKD).Aim: The assessment of late night salivary cortisol concentration, serum and salivary concentration in overnight dexamethasone suppression test in patients with CKD stage III–V and a control group.Patients and methods: 37 patients mean age 66±12 (M=13) with CKD stage III–V...

Recently, 59 percent of European adults was diagnosed with obesity or overweight according to the 2022 Regional Obesity Report presented by the World Health Organization (WHO). Thus, insight into factors implicated in overweight and obesity may have important therapeutic implications. Interestingly, increased cortisol secretion and psychosocial stress have been demonstrated to be related with body weight-dependent insulin resistance and beta cells failure. Thus, the study was ...

Background: Hashimoto’s thyroiditis (HT) is a common autoimmune disorder of the thyroid (AITD) which affects about 1–2% of the European population. The disease often clusters in families, which is why many attempts have been undertaken to find the genetic background that would underly the predisposition to HT. In contrast to another AITD - Graves’ disease, results of genetic analyses have been ambiguous and have failed to find a major genetic locus that would be...