Endocrine Abstracts

Background: Subclinical thyroid hypofunction and elevation of serum lipid concentrations are two factors that may act synergistically in the increase of cardiovascular risk in patients with type 2 diabetes. However, the association between subclinical hypothyroidism and dyslipidemia is a matter of debate.Objective: Our aim has been to assess whether incident hypothyroidism detected in a screening program is accompanied by elevations in the serum concentr...

Purpose: To assess the impact of serum corrected calcium (CorrCa), magnesium (Mg) and phosphorus (P) levels at hospital admission on SARS-CoV-2 infection outcome.Methods: In this retrospective study, all adult patients with laboratory-confirmed COVID-19 hospitalized in Hospital Universitario Puerta de Hierro Madadahonda during 2020 were included. Demographic, clinical and laboratory data were registered and related to the prognosis of the disease. Poor o...

Background: Aggressive prolactinomas are rare neoplasms that are characterized by rapid growth and usually large tumor size, invasion of adjacent structures, an aggressive clinical behavior with little response to conventional treatment, high rate of recurrence, and elevated morbidity and mortality.Case Report: 48-year-old woman diagnosed with life-threatening aggressive prolactinoma was referred to us for evaluation of complementary therapy after therap...

Background: Systematic exploration for anterior pituitary deficiency in patients harboring pituitary microadenomas is not well defined. So far, little is known on the involvement of pituitary function in clinically non-functioning pituitary microadenomas (CNFPM).Objective: To evaluate the prevalence of anterior pituitary insufficiency, defined as at least one hormonal deficiency, in patients diagnosed of CNFPM.Patients and methods:...

Aim: Multidisciplinary approach is mandatory in the management of endocrine tumors. Herein, we summarize the healthcare activity performed during the last 6 years at the multidisciplinary committee for endocrine tumors of a tertiary and University Hospital.Methods: A search of clinical-care activity of the endocrine tumors committee of our hospital from 2011 to 2016 was performed. Clinical and demographic data of all patients were recorded. The committee...

Objetive: To assess the clinical features of incidental clinically non-functioning pituitary adenoma (NFPA) and to analyze its natural history.Methods: A multicenter retrospective study in patients with NFPA followed-up from 1992 to 2015 was performed.Results: Fifty-seven patients were studied (29 women (50.9%); age 55.8±16.7 years. 43.9% were older than 60 years, 40.3% belonged to the age group of 40–60 years and 15.8% w...

Introduction: Hyperprolactinemia has been associated with several metabolic abnormalities both in glucose homeostasis, insulin sensitivity, and in lipid profile. Moreover, it has also been reported that many of them seem to improve after normalizing serum prolactin (PRL) concentrations.Objective: To study serum glucose, cholesterol and triglyceride in men with prolactinoma before and after chronic treatment with cabergoline.Patient...

Objective: To assess clinical outcome after pituitary surgery in patients nonfunctioning pituitary adenomas (NFPA) surgically treated in the past 3 decades in three tertiary referral hospitals.Methods: A multicenter retrospective study on clinical and pathological characteristics, treatment patterns, and outcome in patients with NFPA periodically followed up in specialized neuroendocrinology units who underwent surgery in the period 1982–2015 was pe...

Context: Acromegaly associated to schizophrenia was firstly reported ~60 years ago and, so far it is unclear whether this association is causal or not.Objective: We report on three new cases and discuss the potential pathophysiological mechanisms of this association.Results: We report two males and one female diagnosed with schizophrenia and treated for several years with antipsychotics who developed acromegaly due to a GH-secretin...

Malignant insulinoma is an extremely uncommon tumor (5–10% of insulinomas). It is accompanied by severe hypoglycemia and a short life expectancy (survival at 10 years <10%). Its clinical management is complex and constitutes a real therapeutic challenge. So far, the experience of radionuclide treatment in these tumors is scarce. We report the case of a 51-year-old woman diagnosed with pancreatic neuroendocrine tumor (pNET) in January 2013. Pre-surgical imaging study b...