Searchable abstracts of presentations at key conferences in endocrinology

ea0090p784 | Thyroid | ECE2023

Methimazole induced agranulocytosis - A clinical case report

Menino Joao , Meira Ines , Pedro Jorge , Carvalho Davide , Freitas Paula

Introduction: Antithyroid drugs (ATDs) are generally safe and well tolerated, however, major side effects such as hepatotoxicity and agranulocytosis may occur and patients should be provided information on the major symptoms of these conditions. Although rare, agranulocytosis appears to be more likely with propylthiouracil (PTU) at any dose than with low-dose Methimazole (MMI). Clinical Case: We describe the case of a 70-year-old woman referred to Endocr...

ea0090ep809 | Pituitary and Neuroendocrinology | ECE2023

The importance of Prompt Treatment of Ectopic Cushing Syndrome

Meira Ines , Menino Joao , Pedro Jorge , Carvalho Davide , Freitas Paula

Introduction: Ectopic ACTH production accounts for up to 20 percent of ACTH-dependent Cushing syndrome (CS). Small cell carcinoma and carcinoid of the lung represents half of its cases. These patients lack some of the more obvious clinical features of cortisol excess. Therefore, this can cause a delay in the diagnosis of CS and these patients may be at high risk of life-threatening complications such as infections or thrombosis.Clinical case: Case of a 7...

ea0090ep64 | Adrenal and Cardiovascular Endocrinology | ECE2023

Cushing’s Syndrome due Primary bilateral macronodular adrenal hyperplasia–a case series from a tertiary hospital

Goncalves Juliana , Ferreira Helena Urbano , Pedro Jorge , Carvalho Davide , Freitas Paula

Primary bilateral macronodular adrenal hyperplasia (PBMAH) is a rare cause of Cushing’s syndrome (CS). It is a highly heterogeneous disease with multiple adrenal macronodules and variable levels of cortisol excess. The pathogenesis is complex and different mechanisms such as aberrant hormone receptors, local production of ACTH in adrenal tissues and genetic mutations have been identified. The approach is not well established. Nine patients with PBMAH who are currently fol...

ea0090ep315 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Levothyroxine dosing following bariatric surgery – A 4-year follow up

Ribeiro Sara , Lima Bruno A , Goncalves Juliana , Moreno Telma , Ferreira Helena Urbano , Pedro Jorge , Varela Ana , Carvalho Davide , Freitas Paula

Introduction: The anatomical and physiological changes induced by bariatric surgery (BS) can significantly impact the absorption and pharmacokinetics of orally administered medication. In particular, levothyroxine (LT4) dosage, given its dependence on patient’s weight and gastric pH for optimal absorption, is expected to change following BS. However, the literature is not unanimous and there is a void of longer-term studies. We aimed to compare LT4 dosage 4 years followin...

ea0073aep176 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

COVID-19 and diabetes: Impact on emergency department demand by diabetic patients. experience from a portuguese center

Maria João Ferreira , Pedro Jorge , José Luis Castedo , Pereira Fernando , Carvalho Davide , Tiago Guimarães

IntroductionCOVID-19 is an emerging disease caused by the new coronavirus (SARS-CoV-2) that has overburdened healthcare worldwide. In Portugal, schedule appointments were cancelled, postponed or changed to tele-consultation. The objective of the study is to assess the impact of the pandemic on the use of Emergency Department (ED) by diabetic patients.Material and methodsRetrospective monocentric study of the ...

ea0090ep1095 | Late Breaking | ECE2023

Effectiveness of empirical antibiotic therapy in diabetic foot infection in a Portuguese Center

Goncalves Juliana , Guimaraes Andre , Urbano Ferreira Helena , Ribeiro Sara , Moreno Telma , Borges-Canha Marta , Silva Fabia , Clara Correia Maria , Pedro Jorge , Neves Nelia , Sao Simao Ricardo , Andrade Paulo , de Lurdes Santos Maria , Carvalho Davide , Freitas Paula

Introduction: Diabetic foot infection imposes a significant burden and is a major cause of non-traumatic limb amputation. Antibiotic therapy plays a crucial role in the management these patients. In our institution, empirical antibiotic therapy is tailored to the presence of risk factors for multidrug-resistant microorganisms. For patients without risk factors, empirical intravenous amoxicillin-clavulanate at a dose 2.2 g every 8h is used. For patients with risk factors such a...

ea0049ep719 | Obesity | ECE2017

Testosterone deficiency in obese males: is insulin resistance the one to blame?

Souteiro Pedro , Magalhaes Daniela , Pedro Jorge , Oliveira Sofia Castro , Neves Joao Sergio , Belo Sandra , Costa Maria Manuel , Bettencourt-Silva Rita , Varela Ana , Queiros Joana , Freitas Paula , Carvalho Davide , Group AMTCO

Introduction: Obesity is a growing worldwide public health issue and it is associated with multiple comorbidities, namely the so called Male Obesity-associated Secondary Hypogonadism (MOSH). However, the mechanisms that explain this association are not fully understood.Methods: Cross-sectional study of 163 obese men that were evaluated for several clinical and analytic parameters. Testosterone deficiency was defined as: total testosterone <2.8 ng/ml ...

ea0070aep290 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Magnesium supplementation and higher magnesium levels in T2DM patients are associated with better glycemic control and higher rates of total and partial remission post-bariatric surgery

Silva Maria , Mendonça Fernando , João Fonseca Maria , João Ferreira Maria , Salazar Daniela , Pedro Jorge , Guerreiro Vanessa , Sergio Neves João , Lau Eva , Belo Sandra , Varela Ana , Freitas Paula , Carvalho Davide

Introduction: Magnesium (Mg) is an essential mineral for human health. Chronic Mg2+ deficiency and low Mg2+ dietary intake have been associated with increased risk of T2DM. Despite the increased risk of T2DM associated with Mg2+ deficiency; T2DM is often accompanied by hypomagnesemia, especially in patients with poorly controlled glycemic profiles.Bariatric surgery remains the most effective long-term therapy for the management of patients wi...

ea0070aep378 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Bariatric surgery impact on cardiovascular risk factors: Is age a factor to consider?

Mendonça Fernando , Silva Maria , João Ferreira Maria , Salazar Daniela , Guerreiro Vanessa , Pedro Jorge , Sergio Neves Joao , Viana Sara , Belo Sandra , Varela Ana , Freitas Paula , Carvalho Davide

Introduction: Despite the abundance of data addressing the influence of patient’s age on surgery-related complications, its impact on several cardiovascular risk factors following bariatric surgery has been overlooked.Methods: Retrospective unicentric study of 1728 obese patients who underwent bariatric surgery between January/2010 and June/2015. Patients were divided in three groups, according to their age at surgery: <40 (n = 751...

ea0090ep286 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Prediabetes remission after bariatric surgery: A 4-years follow-up study

Borges-Canha Marta , Neves Joao Sergio , Silva Maria , Mendonca Fernando , Moreno Telma , Ribeiro Sara , Vale Catarina , Goncalves Juliana , Ferreira Helena Urbano , Santos Sara , Calheiros Raquel , Meira Ines , Menino Joao , Guerreiro Vanessa , Pedro Jorge , Varela Ana , Souto Selma , Lima da Costa Eduardo , Freitas Paula , Carvalho Davide , Group CRIO

Background: Bariatric surgery leads to weight loss and to cardiometabolic risk improvement. Although prediabetes remission after bariatric surgery is biologically plausible, data on this topic is scarce.Aim: We aimed to access pre-diabetes remission rate and clinical predictors of remission in a 4 year follow up period.Methods: Observational longitudinal study including patients with morbid obesity and prediabetes submitted to bari...