Searchable abstracts of presentations at key conferences in endocrinology

ea0059pl7 | British Thyroid Association Pitt-Rivers Lecture | SFEBES2018

How should we define optimal thyroid function?

Peeters Robin

It has been known for a long time that both hypo- and hyperthyroidism are associated with an increased risk of morbidity and mortality. In recent years, it has also become clear that minor variations in thyroid function, including subclinical dysfunction and even variation in thyroid function within the reference range, can have important effects on clinical endpoints, such as bone mineral density, depression, metabolic syndrome, and cardiovascular mortality. Serum thyroid par...

ea0026s20.2 | Thyroid function: it is in your genes | ECE2011

Polymorphic variation in thyroid pathway genes

Peeters Robin

Adequate thyroid hormone (TH) levels are essential for normal growth and differentiation, for the regulation of energy metabolism, and for the physiological function of virtually all human tissues. Epidemiological evidence shows that minor variation in TH serum levels, even within the normal range, can have important effects on different TH related clinical endpoints, such as bone mineral density, atrial fibrillation, metabolic syndrome and cardiovascular mortality.<p clas...

ea0019s23 | What is the TSH set point? Does it matter? | SFEBES2009

Genetic determinants of the HPT axis set point

Peeters Robin

In healthy subjects, there is a substantial variability in circulating concentrations of thyroid hormone (TH) between individuals, whereas the variability within an individual over time is usually within a narrow range. It is estimated that about 65% of this variation is genetically determined, resulting in a thyroid function set-point that is different for each individual. The major causative genes are, however, not well established.The biological activ...

ea0044oc6.2 | Pregnancy and Reproductive Health | SFEBES2016

The thyroidal response to hCG stimulation is impaired in women with subclinical hypothyroidism and is influenced by BMI, fetal sex and parity

Korevaar Tim , Chaker Layal , Visser Theo , Peeters Robin

Introduction: Although hCG is an important determinant of gestational thyroid function, it is unknown to what extent hCG is a risk factor for thyroid disease and we also lack knowledge on which characteristics influence the thyroidal response to hCG stimulation.Methods: hCG, TSH, FT4 and TPOAbs were measured in 5435 pregnant women (<18 weeks) in a prospective cohort. Subclinical disease entities were defined according to P2.5-P97.5 in TPOAb negative ...

ea0041oc4.1 | Thyroid - Clinical | ECE2016

Additional measurement of hCG distinguishes physiological high-normal thyroid function and reveals large differences in the risk of developing preeclampsia

Korevaar Tim , Steegers Eric , Medici Marco , Visser Theo , Peeters Robin

Context: Preeclampsia is a leading cause of maternal and perinatal morbidity and mortality worldwide, affecting 2–8% of all pregnancies. We have previously shown that women with high-normal levels of FT4 during early pregnancy have a 2.1-fold increased risk of preeclampsia – but there was no apparent association with low TSH. However, the thyroid is stimulated by human chorionic gonadotropin (hCG) during early pregnancy and therefore we hypothesized that women with h...

ea0081yi3 | Young Investigator Awards | ECE2022

Generalization of TSH and FT4 reference intervals in pregnancy: an individual participant data meta-analysis

Osinga Joris , Derakhshan Arash , Consortium on thyroid and pregnancy working group on reference intervals , Peeters Robin , Korevaar Tim

Objective: Defining thyroid function test abnormalities in pregnancy is complicated by changes in maternal physiology. Ideally, reference intervals (RIs) should be population-based and pregnancy-specific. Large methodological differences between published reports limit the adoption of such RIs into clinical practice.Methods: The study was performed in the Consortium on Thyroid and Pregnancy. In line with current consensus and the 2017 American Thyroid As...

ea0041ep994 | Thyroid (non-cancer) | ECE2016

Sorafenib-induced changes in thyroid hormone levels in patients with hepatocellular carcinoma

Beukhof Carolien , Bins Sander , van Doorn Leni , de Herder Wouter , Visser Theo , Mathijssen Ron , Peeters Robin

Background: Recent studies suggest enhanced peripheral thyroid hormone metabolism as an explanation for the changes in thyroid hormone levels in patient treated with Sorafenib.Methods: In this single centre, prospective, observational cohort study 60 patients with hepatocellular carcinoma were treated with Sorafenib. Thyroid stimulating hormone (TSH) and free thyroxine (FT4) were measured at baseline (time-0), at 6 weeks (time-1) and at the end of therap...

ea0037oc6.2 | Thyroid | ECE2015

Biological activity of novel thyroid hormone analogues: role of Na+ taurocholate cotransporting polypeptide in liver selectivity

Brigante Giulia , Carlsson Bo , Kersseboom Simone , Peeters Robin P , Visser Theo J

Background: The interest in the potential effect of thyromimetics in lowering serum cholesterol is growing. Thyroid hormone actions on lipid metabolism are exerted in the liver and mediated by the T3 receptor TRβ1. The creation of molecules transported into hepatocytes by liver-specific transporters can increase the liver selectivity of thyromimetics. Sodium taurocholate co-transporting polypeptide (NTCP), a solute carrier protein primarily expressed on the basolateral me...

ea0037oc7.1 | Neuroendocrinology and pituitary-basic | ECE2015

Genetic screening of regulatory regions of pituitary transcription factors among patients with idiopathic pituitary hormone deficiencies

Schuilwerve Joyce , Elizabeth Melitza , Peeters Robin , Visser Theo , Hokken-Koelega Anita , de Graaff Laura

Introduction: POU1F1 is a pituitary transcription factor, critical for differentiation of pituitary somatotrophs, thyrotrophs and lactotrophs. POU1F1 expression depends on the presence of PROP1, which attenuates expression of transcriptional repressor HESX1. Previous mutation screening of POU1F1 coding exons in our cohort of patients with combined pituitary hormone deficiency (CPHD) showed POU1F1 mutations in only 1% of the families. We hypo...

ea0037gp.27.06 | Thyroid – hyperthyroidism and treatment | ECE2015

hCG levels are essential for the correct interpretation of gestational TSH levels: the clinical risk assessment of premature delivery

Korevaar Tim , Medici Marco , Chaker Layal , Tiemeier Henning , Visser Theo , Peeters Robin

Context: High maternal TSH and/or low FT4 during pregnancy is associated with an increased risk of premature delivery. hCG is the main determinant of thyroid function changes during pregnancy but has a versatile pattern with high inter and intra-individual variability. We hypothesised that the correct interpretation of thyroid function tests and its use in the risk assessment of premature delivery during pregnancy depend on hCG levels.Design, ...