Searchable abstracts of presentations at key conferences in endocrinology

ea0063gp121 | Diabetes: Late Complications | ECE2019

The A allele of the rs4636297 (G/A) polymorphism in the microRNA-126 is associated with protection for diabetic retinopathy

Crispim Daisy , Massignam Eloisa , Pellenz Felipe Mateus , Dieter Cristine

Background and aims: Diabetic retinopathy (DR) is an important chronic complication of diabetes mellitus (DM), and is the leading cause of new cases of blindness in adults. Although several single nucleotide polymorphisms (SNPs) have been associated with DR, more information is needed to unravel the genetics of this complex disease. MicroRNAs (miRNAs) are a class of small noncoding RNAs that regulate expression of at least 60% of all protein-coding genes. A number of miRNAs ha...

ea0063gp217 | Gestational and Type 1 Diabetes | ECE2019

The rs2304256 A allele in the TYK2 gene is associated with protection for type 1 diabetes mellitus in a Brazilian population

Crispim Daisy , Pellenz Felipe Mateus , Duarte Guilherme , Dieter Cristine , Souza Bianca de

Background and Aims: Type 1 diabetes mellitus (T1DM) is caused by an autoimmune destruction of pancreatic beta cells, which renders patients insulin-dependent for life. The disease arises from a complex interaction among several genetic and environmental factors. To date, single nucleotide polymorphisms (SNPs) in >50 genes have been associated with T1DM, with HLA class II SNPs having the greatest impact on disease susceptibility. Other loci have minor effects on T...