ea0029p1343 | Pituitary Basic | ICEECE2012
Jaffrain-Rea M.
, Angelini M.
, Occhi G.
, Turchi A.
, Castermans E.
, Ceccato F.
, Arcella A.
, Esposito V.
, Giangaspero F.
, Pennelli G.
, Daly A.
, Alesse E.
, Scaroni C.
, Beckers A.
The aryl hydrocarbon receptor interacting protein (AIP) gene is abundantly expressed in normal somatotrophs. Somatotropinomas in patients with germline AIP mutations (AIPmut) are typically more aggressive than non-AIPmut adenomas and associated with higher GH/IGF1 secretion. AIP downregulation may also occur in sporadic somatotropinomas, especially in invasive tumours. We wished to evaluate the impact of somatostatin analogues (SSA) pre-treatment on AIP expression in sporadic ...