Searchable abstracts of presentations at key conferences in endocrinology

ea0070oc2.4 | Bone and Calcium | ECE2020

Loss of glucocorticoid rhythm induces an osteoporotic phenotype in mice

Winter Elizabeth M , Schilperoort M , Kroon J , Kooijman S , Mletzko K , Busse B , Pereira AM , Appelman-Dijkstra NM , Bravenboer N , Rensen PCN , Meijer OC

Introduction: Glucocorticoid (GC)-induced osteoporosis is a widespread problem that is accompanied with increased fracture risk. Currently, it is unknown whether detrimental effects of GC therapy on bone are simply the consequence of supraphysiological GC doses, or whether absence of the endogenous GC rhythm also plays a role. In this study, we aimed to elucidate the importance of the presence of a diurnal corticosterone (CORT) rhythm, the primary GC in mice, for bone quality....

ea0011p472 | Endocrine tumours and neoplasia | ECE2006

Stimulated and spontaneous growth hormone release in irradiated acromegalic patients

van der Klaauw AA , Pereira AM , van Thiel SW , Smit JWA , Corssmit EPM , Biermasz NR , Frohlich M , Iranmanesh A , Veldhuis JD , Roelfsema F , Romijn JA

Growth hormone deficiency frequently occurs as consequence of radiation therapy in pituitary disorders. However, it not known whether radiation therapy in acromegaly results in comparable diminution of GH secretion. We therefore hypothesized that stimulated and spontaneous GH release is ultimately indistinguishable in irradiated acromegalic patients and irradiated patients with other pituitary disorders. For this study 10 acromegalic patients and 10 patients with other pituita...