Searchable abstracts of presentations at key conferences in endocrinology

ea0063gp224 | Adrenal and Neuroendocrine - Clinical (1) | ECE2019

Caffeine upregulates hepatic SHBG production by increasing adiponectin in white adipose tissue

Brianso-Llort Laura , Fuertes-Rioja Lidia , Perez Lorena Ramos , Hernandez Cristina , Simo Rafael , Selva David

Epidemiological studies have shown that caffeine increases plasma SHBG levels and also reduce the risk of type 2 diabetes. There are no reports describing any molecular mechanism by which caffeine regulates hepatic SHBG production. The aim of the present study was to explore whether caffeine regulates SHBG production and to determine the associated molecular mechanisms. For this purpose, in vitro and in vivo studies were performed using human HepG2 cells and ...