Searchable abstracts of presentations at key conferences in endocrinology

ea0016p439 | Neuroendocrinology | ECE2008

A comparison between three automated chemiluminescence assays for growth hormone: on the use of recombinant hGH as a primary calibrant

Arafat Ayman M , Mohlig Matthias , Weickert Martin O , Perschel Frank H , Purschwitz Johannes , Spranger Joachim , Strasburger Christian J , Schofl Christof , Pfeiffer Andreas FH

Objectives: GH measurements during OGTT have profound effects on therapy and follow-up management of acromegaly. To minimize the discordance between immunoassays, it is recommended to calibrate them using 22 kDa-GH-preparation instead of the use of pituitary-derived calibrants. The aim of our study was to evaluate the between-method discrepancies in GH determinations by assays using different calibrants considering further confounders like age, gender, and BMI.<p class="ab...

ea0016p541 | Obesity | ECE2008

Glucagon suppression of total but not of acylated ghrelin is preserved in obesity: the impact on appetite control

Arafat Ayman M , Adamidou Aikaterini , Otto Barbel , Weickert Martin O , Perschel Frank H , Spranger Joachim , Schofl Christof , Mohlig Matthias , Pfeiffer Andreas F H

Objective: The mechanisms underlying the well known glucagon-induced satiety effect are unclear. As we showed recently, the glucagon-induced reduction in total ghrelin, that might be responsible for this effect, is exerted at hypothalamus¬Ėpituitary level. The aim of the present study was to further evaluate glucagon¬ís suppressive effect on both total and acylated-ghrelin in obesity with respect to its role in appetite control.Methods: Prospecti...

ea0014oc8.1 | Neuroendocrinology clinical | ECE2007

Growth hormone response during OGTT: the impact of assay method, gender and BMI on the estimation of reference values in patients with acromegaly and in healthy controls

Arafat Ayman M , Möhlig Mathias , Weickert Martin O , Perschel Frank H , Purschwitz Johannes , Spranger Joachim , Strasburger Christian J , Schöfl Christof , Pfeiffer Andreas FH

Objectives: Besides the measurement of IGF-1, GH suppression during OGTT to assess the biochemical status in acromegaly is recommended. However, as a consequence of the development of highly sensitive and specific GH assays a critical re-evaluation of the criteria for the diagnosis and follow-up management of acromegaly is mandatory. The aim of our study was to evaluate the between-method discrepancies in GH determinations by different immunoassays considering further confound...