Searchable abstracts of presentations at key conferences in endocrinology

ea0016p654 | Signal transduction | ECE2008

Melatonin acts on pancreatic β-cells via melatonin receptors using the cAMP-, IP3- and probably also the cGMP-signalling pathway

Stumpf Ina , Muhlbauer Eckhard , Peschke Elmar

Physiological and molecular examinations provided evidence for the receptor-mediated influence of the pineal hormone melatonin on insulin secretion of pancreatic β-cells. The predominant effect is a reduction the rate of insulin secretion transmitted by downregulation of intracellular cAMP concentrations. In addition, there is also evidence for an activation of the PLC-IP3-pathway. Further investigations established the existence of the melatonin-receptor MT1, ...

ea0016p183 | Diabetes and cardiovascular diseases | ECE2008

Melatonin--insulin relationships in rats and humans

Peschke Elmar , Frese Thomas , Wolgast Sabine , Bazwinsky Ivonne , Muhlbauer Eckhard

There is a well documented link between melatonin and insulin. Morphological, molecular and functional investigations have shown that the pineal hormone melatonin (MT) influences the insulin secretion. The effects were mediated by specific, high-affinity, pertussis-toxin-sensitive, G-protein-coupled MT1- as well as MT2-membrane receptors which were detected in pancreatic tissue and islets of rats and humans and additionally in rat insulinoma cells INS1. Using the Gi-protein-ad...