ea0016p183 | Diabetes and cardiovascular diseases | ECE2008
, Frese Thomas
, Wolgast Sabine
, Bazwinsky Ivonne
, Muhlbauer Eckhard
There is a well documented link between melatonin and insulin. Morphological, molecular and functional investigations have shown that the pineal hormone melatonin (MT) influences the insulin secretion. The effects were mediated by specific, high-affinity, pertussis-toxin-sensitive, G-protein-coupled MT1- as well as MT2-membrane receptors which were detected in pancreatic tissue and islets of rats and humans and additionally in rat insulinoma cells INS1. Using the Gi-protein-ad...