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ea0011p304 | Diabetes, metabolism and cardiovascular | ECE2006

Serum ghrelin levels during oral glucose challenge – new insights from gastrectomized patients

Miljic D , Pekic S , Pesko P , Djurovic M , Doknic M , Glodic J , Dieguez C , Casanueva FF , Popovic V

Ghrelin is gastric peptide with appetite stimulating and growth hormone (GH) releasing properties. Circulating ghrelin levels decrease after nutrient ingestion, oral and iv glucose challenge. It has been hypothesized that vagal system may have a major role in initiating this decrease.The aim of this study was to investigate circulating ghrelin levels during oral glucose challenge in gastrectomized (GASTRX)- vagotomized patients. The study was approved by...

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ea0008p20 | Cytokines and growth factors | SFE2004

Low circulating ghrelin levels in gastrectomized patients do not affect the growth hormone response to insulin induced hypoglycemia

Miljic D , Pekic S , Pesko P , Djurovic M , Doknic M , Petakov M , Damjanovic S , Micic D , Cvijovic G , Diguez C , Casanueva FF , Popovic V

Ghrelin is a potent growth hormone (GH) secretagogue in rats and in humans. Since stomach is the main source of circulating ghrelin, gastrectomy reduces plasma ghrelin concentrations by 65%. The implications of decreased circulating ghrelin on GH secretion have not yet been investigated. Furthermore, the neuroendocrine pathways through which ghrelin acts to release GH are largely unknown. We aimed to investigate GH response after insulin induced hypoglycemia (ITT) and after sy...

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Endocrine Abstracts

Serum ghrelin levels during oral glucose challenge – new insights from gastrectomized patients

Low circulating ghrelin levels in gastrectomized patients do not affect the growth hormone response to insulin induced hypoglycemia

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