Endocrine Abstracts

The human prostate is highly susceptible to benign and malignant proliferative changes and is associated with the development of benign prostatic hyperplasia (BPH) and prostate cancer (PCa), two of the most common diseases affecting elderly males. The diseased-associated stroma undergoes significant remodelling, including fibroblast-to-myofibroblast/smooth muscle cell transdifferentiation. Subsequent increased secretion of cytokines and growth factors generates a growth favour...

Benign prostatic hyperplasia (BPH) is characterized by tissue overgrowth and stromal reorganization primarily due to cellular proliferation and fibroblast-to-myofibroblast transdifferentiation. Given the recently reported beneficial effects of PDE5 inhibitors on lower urinary tract symptoms secondary to BPH this study aimed to investigate the influence of PDE5 inhibition on the prostate at a cellular level. We investigated the expression of PDE5 in the human prostate and demon...

Prostate homeostasis and function are regulated by complex interactions between the fibromuscular stroma and secretory epithelium via locally-derived and systemic paracrine- and autocrine-acting growth factors and sex steroid hormones. Stromal tissue remodelling due to alterations in transforming growth factor beta (TGF-β) and sex steroid hormone signalling are associated with benign prostatic hyperplasia (BPH) and prostate cancer (PCa), two of the most common proliferati...