Searchable abstracts of presentations at key conferences in endocrinology

ea0037ep193 | Reproduction, endocrine disruptors and signalling | ECE2015

PZ-TR: a novel human luciferase reporter cell line for assessment of thyroid receptor transcriptional activity

Illes Peter , Dvorak Zdenek

Regulation of gene expression mediated by thyroid hormones (THs) plays an essential role in variety of physiological processes. It is known that large group of natural and synthetic compounds, generally termed endocrine disruptors, can interfere with endocrine system and thus disrupt homeostasis of hormonal regulation processes in human organism. In order to screen for substances with potential disrupting effects on TH pathway, we developed and characterized human luciferase r...

ea0049ep803 | Nuclear receptors and Signal transduction | ECE2017

Development of novel human stable reporter cell line for the assessment of PPARγ transcriptional activity

Illes Peter , Grycova Aneta , Prichystalova Hana

Endocrine disrupting chemicals (EDCs) are exogenous compounds that affect the endocrine system, disrupt the hormonal balance and consequently cause the adverse health effects in humans. These compounds persist and accumulate in the environment and can easily gain entry to the food chain. Peroxisome proliferator-activated receptor gamma (PPARγ) and its heterodimeric partner retinoid X receptor alpha (RXRα) are very often targets of EDCs. PPARγ play crucial role i...

ea0041ep776 | Nuclear receptors and Signal transduction | ECE2016

Effect of anthocyanidins on trascriptional activities of steroid and nuclear receptors

Pastorkova Barbora , Illes Peter , Dvorak Zdenek

Anthocyanidins are aglycons of anthocyanins, which are plant pigments responsible for floral and fruits color. Anthocyanidins possess beneficial pharmacological properties such as antioxidant, anti-inflammatory, anti-tumor and anti-diabetic. Anthocyanidins are contained in normal diet and might play role in food-drug interactions.The aim of current study was to evaluate the effects of cyanidin, delphinidin, malvidin, pelargonidin and peonidin on the tran...