Searchable abstracts of presentations at key conferences in endocrinology

ea0090ep25 | Adrenal and Cardiovascular Endocrinology | ECE2023

Endocannabinoids in patients with adrenal incidentalomas. A new prognostic biomarker?

Mytareli Chrysoula , Athanasouli Fani , Karampela Athina , Papalexis Petros , Siampanopoulou Vasiliki , Lafioniatis Alexandros , Mantzourani Marina , Angelousi Anna

Background: The majority of adrenal incidentalomas (AIs) are benign non-functioning adrenocortical adenomas (NFAIs), yet not clinically silent. Possible autonomous cortisol secretion (PACS) can also be diagnosed in up to 50% of patients. Endocannabinoids (ECs) have recently been studied regarding their role in the hypothalamo-pituitary-adrenocortical (HPA) axis; however, data are scarce in humans.Aim: We aimed to assess hair EC [anandamide (AEA) and 2-ar...

ea0090ep173 | Calcium and Bone | ECE2023

The effect of Immune Checkpoint Inhibitors (ICIs) in Bone Metabolism: A case series analysis

Siampanopoulou Vasiliki , Angelousi Anna , Karampela Athina , Papalexis Petros , Lafioniatis Alexandros , Mytareli Chrysoula , Ziogas Dimitrios , Gogas Helen , Kassi Evanthia

Background: Immune checkpoint inhibitors (ICIs) constitutes a novel treatment for patients with melanoma. Endocrine-related adverse effects are now a distinctive clinical entity of ICIs, with hypophysitis and thyroiditis being the most common. Recent consensus doesn’t suggest routinely screening of bone mass indexes in patients on ICIs since data in the literature are scarce.Methods: Data regarding bone disease were retrospectively analysed in 118 p...

ea0037ep300 | Calcium and Vitamin D metabolism | ECE2015

Anti-diabetic treatment as an additional factor in a FRAX based evaluation of osteoporotic fracture risk

Yavropoulou Maria P , Mousiolis Athanasios , Kolokouri Vasiliki , Kolimpianaki Pelagia , Dimitriou Athina , Papalexis Petros , Daniilidis Michael , Kotsa Kalliopi

Background: The present study is designed to assess the incidence of osteoporotic fractures and the associated risk factors and particularly those used to predict the 10-year fracture risk in FRAX score based on data gathered in general practitioner’s records of rural Greece.Patients and methods: We conducted a retrospective analysis of all patients with osteoporosis presented between October 2013 and December 2014. Data from medical records includi...

ea0099ep258 | Adrenal and Cardiovascular Endocrinology | ECE2024

Psychometric parameters and quality of life in patients with adrenal tumours

Charikleia Tasouli Elisavet , Mytareli Chrysoula , Andreadaki Evangelia , Thanasoula Foteini , Siampanopoulou Vasiliki , Karabela Athina , Papalexis Petros , Lafioniatis Alexandros , Angelousi Anna

Introduction: Neuropsychiatric disorders are common and well-studied in patients with overt hypercortisolism. However, data regarding patients with adrenal incidentalomas (AIs) are limited. The aim of our study is to assess the psychometric and quality of life status in individuals with benign adrenal tumours.Methods: Eighty-two patients diagnosed with AIs, encompassing 53 females and 29 males, with a total mean age of 64 years and 52controls (without AI...

ea0099ep142 | Endocrine-Related Cancer | ECE2024

Magnetic resonance imaging in patients with immune check point inhibitors induced hypophysitis

Karampela Athina , Angelousi Anna , Savelli Akrivi , Papalexis Petros , Siampanopoulou Vasiliki , Lafioniatis Alexandros-Aristeidis , Leontari Ekaterini , Diamantopoulos Panagiotis , Gogas Helen

Introduction: Immune checkpoint inhibitors (ICIs), are widely used as therapeutic option in oncological patients. However, ICIs treatment is often complicated by endocrinological adverse events, such as hypophysitis. Although diagnostical approach of hypophysitis is standardized, imaging features have not been characterized yet. Methods: Pituitary gland magnetic resonance imaging (MRI) findings were retrospectively recorded in 59 oncological patients wit...

ea0090ep593 | Endocrine-related Cancer | ECE2023

Endocrinopathies in oncological patients treated with immunotherapy: A real world data study

Angelousi Anna , Karampela Athina , Kazanas Spyridon , Papalexis Petros , Lafioniatis Alexandros , Siampanopoulou Vasiliki , Mytareli Chrysoula , Theochari Maria , Stephanou Dimitra , Ziogas Dimitrios , Gogas Helen

Background: Immune checkpoint inhibitors (ICIs) (anti-CTLA-4, PD-1 inhibitors, PD-L1 inhibitors) are considered a widely used therapeutic choice for several cancer types. However ICI therapy is frequently complicated by adverse events; endocrine toxicities are the most common ones.Methods: To assess in a retrospective observational study in a tertiary hospital the incidence and the characteristics of the immunotherapy-related endocrine adverse events (ir...

ea0099ep334 | Calcium and Bone | ECE2024

Bone disorders in oncological patients treated with Immune-Checkpoint Inhibitors (ICIs)

Siampanopoulou Vasiliki , Angelousi Anna , Lyrarakis George , Karampela Athina , Papalexis Petros , Lafioniatis Alexandros , Mytareli Chrysoula , Tasouli Elisavet , Ziogas Dimitrios , Kassi Evanthia , Gogas Helen

Background: The use of immune checkpoint inhibitors (ICIs) has been lately established as a promising and effective treatment in several solid malignancies. Endocrine-related adverse effects are common, however their effects on bone metabolism is unknown.Methods: We retrospectively investigated the prevalence of bone-related complications in patients undergoing or completing treatment with ICIs. Epidemiological and clinical data from the medical files of...