Searchable abstracts of presentations at key conferences in endocrinology

ea0021oc5.2 | Steroids and thyroid | SFEBES2009

De novo cortisol synthesis by primary human keratinocytes

Hannen Rosalind , Michael Anthony , Burrin Jacky , Philpott Micheal

Cortisol-based therapy is still the most potent anti-inflammatory treatment available for skin conditions such as psoriasis and atopic dermatitis. Previous studies have demonstrated the presence of components of the steroidogenic pathway in keratinocytes, though surprisingly none have reported that these cells, which form up to 90% of the epidermis are able to synthesise cortisol1,2. Here, we demonstrate that primary human keratinocytes (PHK) are capable of de no...