Searchable abstracts of presentations at key conferences in endocrinology

ea0063gp263 | Thyroid Nodules and Cancer 2 | ECE2019

Predictive factors of short and long-term vandetanib response in locally advanced or metastatic medullary thyroid cancer: a single center experience

Valerio Laura , Bottici Valeria , Matrone Antonio , Tacito Alessia , Romei Cristina , Piaggi Paolo , Elisei Rossella

Objectives: Vandetanib (V) is an important drug in the metastatic medullary thyroid cancer (MTC) treatment. The objective of this study was to evaluate the presence of predictors of V response, in short and long period, in locally advanced or metastatic MTC patients (pts).Methods: Seventy-nine locally advanced or metastatic MTC pts with progressive or symptomatic disease, referred to our Center between 2007 and 2018 and already treated surgically and wit...

ea0084ps3-14-126 | Thyroid Cancer CLINICAL 2 | ETA2022

The prognostic role of chromosomal gains and loss in sporadic medullary thyroid carcinoma

Ramone Teresa , Ciampi Raffaele , Casalini Roberta , Valetto Angelo , Bertini Veronica , Piaggi Paolo , Elisei Rossella , Romei Cristina

Background: Human cancer is characterized by the accumulation of somatic alterations including base substitutions, indels, structural rearrangements and somatic copy number alteration (CNA), either gain or loss, of chromosomes that can be responsible either for initiation and/or cancer progression. About 80% of Sporadic Medullary Thyroid Carcinoma (sMTC) harbor RET or RAS somatic alterations with a negative prognostic role for the presence of the RET mutation; a few s...

ea0073aep875 | Late Breaking | ECE2021

Management of thyrotoxicosis induced by PD1 or PD-L1 blockade

Brancatella Alessandro , Lupi Isabella , Viola Nicola , Daniele Sgrò , Montanelli Lucia , Sardella Chiara , Molinaro Eleonora , Piaggi Paolo , Elisei Rossella , Marcocci Claudio , Santini Ferruccio , Latrofa Francesco

BackgroundThyrotoxicosis is a common immune-related adverse event in patients treated with PD1 or PD-L1 blockade. A detailed endocrinological assessment, including thyroid ultrasound and scintigraphy is missing, as are data on response to treatment and follow-up. Aim of the study was to better characterize the thyrotoxicosis secondary to immune checkpoint inhibitors, gaining insights into pathogenesis and informing management.Metho...

ea0081p296 | Calcium and Bone | ECE2022

Risk factors for renal calcifications and determinants of hypercalciuria in patients with chronic, post-surgical hypoparathyroidism

Mazoni Laura , Matrone Antonio , Apicella Matteo , Piaggi Paolo , Saponaro Federica , Borsari Simona , Pardi Elena , Cosci Bianca , Biagioni Isabella , Rossi Piercarlo , Pacciardi Federica , Scionti Alessandra , Elisei Rossella , Marcocci Claudio , Cetani Filomena

Conventional therapy with oral calcium supplements and activated vitamin D is the most diffuse and available therapy for chronic hypoparathyroidism (HypoPT). This treatment does not replace the lack of PTH and is associated with renal complications. We report the results of a case control study with a prospective design which included 178 adult patients with differentiated thyroid cancer treated with total thyroidectomy with a follow-up longer that 3 years after surgery: 89 wi...

ea0070aep914 | Thyroid | ECE2020

Thyroid imaging in the management of anti-PD1/PD-L1 induced thyrotoxicosis

Brancatella Alessandro , Lupi Isabella , Viola Nicola , Sgrò Daniele , Antonangeli Lucia , Montanelli Lucia , Sardella Chiara , Brogioni Sandra , Ricci Debora , Bianchi Francesca , Piaggi Paolo , Santini Ferruccio , Marcocci Claudio , Latrofa Francesco

Context: Thyrotoxicosis is the most common endocrine adverse event due totreatment with anti-PD1 and anti-PD-L1. The most common form is destructive thyrotoxicosis whereas persistent, supposedly autoimmune hyperthyroidism (Graves’ hyperthyroidism) is rare. The possible role of thyroid imaging (neck ultrasound and scintigraphy) in the differential diagnosis has never evaluated.Aim: To evaluate the usefulness of neck ultrasound and 99Tc- s...