ea0049oc7.4 | Cardiovascular endocrinology (1) | ECE2017
Vitali Eleonora
, Piccinini Sara
, Boemi Ilena
, Tresoldi Alberto
, Zerbi Alessandro
, Carnaghi Carlo
, Spada Anna
, Lania Andrea
Metformin (1.1-dimethylbiguanide hydrochloride), a widely used antidiabetic drug, has been reported to display potent anticancer properties in various types of cancers, including neuroendocrine tumors. Recently, a potential synergistic activity between metformin and octreotide (SSA) in Pancreatic Neuroendocrine Tumors (P-NETs) has been proposed. AIP (aryl hydrocarbon receptor-interacting protein) acts as tumor suppressor gene in neuroendocrine tumors at pituitary level and it ...