Searchable abstracts of presentations at key conferences in endocrinology

ea0063p798 | Thyroid 2 | ECE2019

Value and limitation of serum MMP-9 in thyroid nodular disease

Dobrescu Ruxandra , Picu Catalina , Manda Dana , Caragheorgheopol Andra , Badiu Corin

Background: Matrix metalloproteinase-9 (MMP-9) is overexpressed in almost all human cancers (including thyroid). High serum levels are generally associated with an adverse prognosis, although the evidence related to thyroid cancer is still controversial.Aim: We aimed to evaluate pre- and post-surgical serum MMP-9 levels for its diagnostic and prognostic value in a series of patients with benign thyroid disease (BD) or differentiated thyroid carcinoma (DT...

ea0070aep945 | Thyroid | ECE2020

MMP-9 1562 C/T polymorphism may be associated with an increased susceptibility to develop micropapillary thyroid cancer but not more advanced tumours

Dobrescu Ruxandra , Schipor Sorina , Picu Catalina , Manda Dana , Caragheorgheopol Andra , Badiu Corin

Background: Matrix metalloproteinase-9 (MMP-9) is an important mediator of invasion and metastasis in neoplasia. The single nucleotide 1562 C/T polymorphism in the promoter region of the MMP-9 genewas shown to increase gene expression and was studied as a susceptibility factor for various cancers.Aim: We aimed to evaluate the impact of the MMP-9 promoter genotype on the risk of developing papillary thyroid cancer (PTC) and to correlate cancer patient gen...

ea0049ep1094 | Endocrine tumours and neoplasia | ECE2017

Study of CYP17 and PSA G158A polymorphisms in prostate cancer

Vladoiu Suzana , Manda Dana , Oros Sabina , Schipor Sorina , Preda Adrian , Gener Ismail , Picu Catalina , Rosca Roxana , Badiu Corin

The relationship between the level of genetic variation in CYP17, PSA genes and prostate cancer has been extensively studied but the results are still unclear. A 450c17a (CYP17) polymorphism A1/A2 was described to be significantly associated to prostate cancer. A SNP in the promotor PSA gene is an A to G substitution at position −158 (G158A) was proposed to interact differently with AR, thereby modifying the expression pattern and occurrence of prostate cancer.<p cla...

ea0049ep1466 | Thyroid (non-cancer) | ECE2017

Association between preoperative serum MMP-9 and histopathological features of thyroid tumors

Dobrescu Ruxandra , Picu Catalina , Schipor Sorina , Padure Adriana , Parvu Liliana , Manda Dana , Ioachim Dumitru , Badiu Corin , Caragheorgheopol Andra

Introduction: Matrix metalloproteinase-9 (MMP-9) is a zinc dependent proteolytic enzyme used by cells for degradation of the extracellular matrix during invasion and migration. There are only a few reports regarding the role played by MMP-9 in papillary thyroid carcinoma (PTC).Aim: To evaluate the association between MMP-9 secretion, reflected by preoperative serum levels and the histopathological features of thyroid tumors.Materia...

ea0041gp232 | Thyroid Cancer (1) | ECE2016

Does serum Galectin-3 add value in thyroid cancer diagnosis?

Dobrescu Ruxandra , Schipor Sorina , Manda Dana , Picu Catalina , Giulea Cosmin , Niculescu Ana-Maria , Badiu Corin , Caragheorgheopol Andra

Background: The role of circulating Galectin-3 as a potential biomarker of malignancy in thyroid disease remains inconclusive. In a previous pilot study we reported a significant difference between serum Gal-3 levels in papillary thyroid carcinoma (PTC) patients and those with benign pathology, but no association with tumor aggressiveness.Aim: We measured serum Gal-3 levels in a larger series of patients submitted to thyroidectomy, in order to assess its...

ea0049ep1216 | Clinical case reports - Thyroid/Others | ECE2017

miRNAs microarray differential profile in papillary thyroid carcinoma

Schipor Sorina , Niculescu Ana-Maria , Botezatu Anca , Ioachim Dumitru , Manda Dana , Caragheorgheopol Andra , Picu Catalina , Popa Oana , Nedelcu Ioana , Badiu Corin

Introduction: The deregulation in miRNA expression has been described in thyroid tumors, and is considered an important factor in thyroid carcinogenesis. mRNA expression profiling in cancer allows identifications of signatures associated with diagnosis, staging, prognosis, and response to treatment.Objective: We aimed to detect miRNAs species differentially expressed between tumor and peritumoral tissue in papillary thyroid carcinoma.<p class="abstex...