Searchable abstracts of presentations at key conferences in endocrinology

ea0035p54 | Adrenal cortex | ECE2014

Effects of non-physiological concentrations of glucocorticoids on apoptotic cell death of human early hematopoietic stem/progenitor cells: in vitro studies

Kawa Milosz , Piecyk Katarzyna , Sobus Anna , Michalska Agata , Roginska Dorota , Ustianowski Przemyslaw , Syrenicz Anhelli , Machalinski Boguslaw

Objectives: Glucocorticoids (GCs) intervene in different physiological activities in almost all systems of the human organism. However, GCs are also potent inducers of apoptosis in many cell types and tissues. It is known, that glucocorticoid-induced apoptosis affects the musculoskeletal system, circulatory system, nervous system, endocrine system, reproductive system, and the immune system. Nevertheless, the exact mechanisms of GCs action in human normal hematopoiesis are sti...

ea0035p339 | Developmental Endocrinology | ECE2014

Influence of growth hormone therapeutic supplementation on early hematopoietic stem/progenitor cells in patients with growth hormone deficiency (GHD).

Kawa Milosz , Stecewicz Iwona , Pius-Sadowska Ewa , Paczkowska Edyta , Piecyk Katarzyna , Gawrych Elzbieta , Petriczko Elzbieta , Walczak Mieczyslaw , Machalinski Boguslaw

Objectives: GH plays a crucial role in the regulation of metabolism of human cells. Nevertheless, a direct influence of this hormone on the proliferation, maturation and differentiation of human early hematopoietic stem/progenitor cells (HSPCs) has not been investigated thoroughly. Moreover, certain deviations of hematological parameters, such as anemia or leucopenia, are commonly observed in patients with growth hormone deficiency (GHD) syndrome, which might be substantially ...