Endocrine Abstracts

Objective: Endocannabinoids (CBs) are novel lipid mediators that modulate appetitive behaviour and energy metabolism. The overactivation of the endocannabinoid system plays an important role in obesity. Endocannabinoids may regulate the lipid metabolism through their receptors (CB1 and CB2) in liver and adipose tissue. 11β-hydroxysteroid dehydrogenase (11β-HSD1) type 1 regulates the local availability of active glucocorticoid, potent inductors of adipogenic different...

Introduction: In humans, testosterone treatment affects body fat distribution and metabolism. The mechanisms involved in these processes are not yet fully understood. We investigated whether sex hormones modulate the expression and activity of type1 11-β-hydroxy-steroid-dehydrogenase (11β-HSD1). 11β-HSD1 catalyses the conversion of inactive cortisone into active cortisol, a key step for the development of functional adipocytes. Based on previous studies an inhib...