Searchable abstracts of presentations at key conferences in endocrinology

ea0092op-08-04 | Oral Session 8: Hypothyrodism / Nodules | ETA2023

Testing for a causal role of thyroid hormone measurements within the normal range: a systematic mendelian randomization study

Alwan Heba , Luan Jian'an , Williamson Alice , Steward Isobel , Wareham Nick , Langenberg Claudia , Pietzner Maik

Background: Numerous observational studies suggested that variation in thyroid function parameters even within the normal range associates with adverse, in particular non-thyroidal, health outcomes, but causality for most remains to be established.Methods: We combined individual level and summary level genetic prediction methods, i.e., polygenic scores and Mendelian randomization (MR), to systematically test for an association between liability to variat...

ea0041oc4.2 | Thyroid - Clinical | ECE2016

Molecular fingerprint of experimental thyrotoxicosis on human metabolism: combined metabolome and proteome study

Pietzner Maik , Engelmann Beatrice , Kacprowski Tim , Golchert Janine , Dirk Anna-Luise , Homuth Georg , Hammer Elke , Nauck Matthias , Wallaschofski Henri , Munte Thomas , Friedrich Nele , Volker Uwe , Brabant Georg

The functional state of the thyroid is usually determined by thyrotropin (TSH), whose serum levels depend on circulating thyroid hormone (TH) levels. This feedback mechanism is tightly controlled in the individual and contrasts broad reference range for TSH in the general population, leading to the concept of subclinical thyroid disease. We studied a model of experimental thyrotoxicosis in humans employing an untargeted metabolome and proteome approach. This allowed us to gain...

ea0056p1040 | Thyroid (non-cancer) | ECE2018

A thyroid hormone-independent molecular fingerprint of 3,5-diiodothyronine suggests a strong relation with coffee metabolism in humans

Pietzner Maik , Homuth Georg , Kohrle Josef , Budde Kathrin , Kastenmuller Gabi , Brabant Georg , Volzke Henry , Artati Anna , Adamski Jerzy , Volker Uwe , Nauck Matthias , Friedrich Nele

Background: Numerous animal models have shown impressive beneficial metabolic effects of the putative thyroid hormone (TH)-derivative 3,5-diiodothyronine (3,5-T2), including the prevention of insulin resistance or the reversal of hepatic steatosis, in the absence of thyrotoxic side effects. In contrast, the endogenous fate of 3,5-T2 in humans is still unclear. Comprehensive molecular profiling holds promise to gain deeper insights in metabolic alterations associated with serum...

ea0084op-08-37 | Oral Session 8: Basic 2 | ETA2022

Resistance to thyroid hormone alpha: molecular, biochemical and physiological approach to diagnosis and therapy

Agostini Maura , Pietzner Maik , Marelli Federica , Prapa Matina , Moran Carla , Edward Visser W. , Brown Dave , Thomas Ellen , Schoenmakers Erik , Romartinez-Alonso Beatriz , Scheuplein Rabea , Tylki-Szymanska Anna , Lyons Greta , Watson Laura , Rajanayagam Odelia , Schwedhelm Edzard , F. Hartmann Michaela , Wudy Stefan , Probst Maiken , MacDonald Stephen , Thomas William , Arlt Wiebke , Volker Uwe , M. Main Katharina , Feldt-Rasmussen Ulla , T. Dattani Mehul , Koren Dahll Louise , Demir Korcan , Kara Cengiz , Kirbiyik Ozgur , Mammadova Jamala , Cayır Atilla , Yarali Oguzhan , Phan-Hug Franziska , Sakremath Rajesh , Mohamed Zainaba , Shinawi Marwan , Gill Harpreet , pacaud Daniele , Perrier Renee , Poke Gemma , Hunter Wendy , Douzgou Sofia , Wakeling Emma , Gardham Alice , Lim Derek , Shears Deborah , Freel Marie , Omladic Jasna , Tansek Mojca , Writzl Karin , Farooqi Sadaf , Kopp Peter , Schwabe John , Persani Luca , Chatterjee Krishna

Objectives: THRA mutations cause Resistance to Thyroid Hormone α (RTHα), an underdiagnosed disorder with hypothyroid features but near-normal thyroid function tests (TFTs). We developed a pathway, combining molecular analyses, new biomarkers and physiological measurements, to better diagnose and treat this disorder.Methods: Structural and functional analyses of THRA variants, discovered by next generation sequencing in specifi...