Endocrine Abstracts

Context: The prevalence of reproductive dysfunction among patients with acromegaly (ACRO) and Cushing’s disease (CD) is high enough, and menstrual disturbances are often the first clinical symptoms of the disease. Objective. The purpose of this study was to assess the functioning of the pituitary-ovarian axis by examination of key hormones.Methods and patients: The study included 58 patients of reproductive age, 21 with ACRO, the average age was 36....

Introduction: Acromegaly is a chronic, debilitating disorder caused by excessive growth hormone (GH) production predominantly due to a benign pituitary adenoma. The overall annual incidence of acromegaly is approximately 3.3 cases/million, with a prevalence of 58–130 cases/million people. Early carbohydrate metabolism disorders (ECMDs) are frequently associated with acromegaly. ECMDs – defined as IFG, IGT or their combination – its prevalence in patients with ac...

Aim: Clinical guidelines recommend the cancellation of dopamine agonists after confirmation of pregnancy as because further their use is unnecessary. However, an implementation of these recommendations in real clinical practice is unknown which became the aim of our present research.Materials and methods: The study included 21 patients with prolactinomas who had 26 pregnancies ended in childbirth. These patients were found archived medical records of End...

Introduction: Vitamin D is involved not only in the regulation of calcium–phosphorus metabolism; it also plays an important role in maintaining the immune system, muscle strength and neuromuscular conduction. Lack of vitamin D is assumed as one of the mechanisms of autoimmune and infectious diseases. Chronic fatigue syndrome (CFS) – is a syndrome manifesting with a severe chronic physical, mental weakness, psychological disturbances such as anxiety and depression, th...

Objectives: To study the prevalence and causes of hyponatremia in patients with various endocrine diseases.Methods: We had retrospectively analyzed the results of biochemical laboratory studies performed during one calendar month at the tertiary care clinic for endocrinology patients for the variations in the serum sodium concentrations. Blood sodium levels <135 mmol/l were considered as hyponatremia. For all patients with hyponatriemia addition data...

Hypothalamic neuropeptides as biomarkers for water-electrolyte disturbances. Introduction Diabetes insipidus is a rare condition characterized by excretion of large amounts of dilute urine and increased thirst. Nephrogenic diabetes insipidus (NDI) is caused by the inability of the kidneys to concentrate urine in response to vasopressin.Aim: The aim of our case report is to present the patient with NDI and to report the data on physiological changes in hy...

Introduction: Prolactinoma is the most commonly occurring hormonally active pituitary tumor. In most cases, dopamine receptor agonists (DA) as a monotherapy are effective. However, approximately 10% of patients with prolactinomas fail to achieve normalization of serum prolactin levels during treatment with DA, which indicates resistance to this group of drugs.Aims: The goal was to study the pharmacokinetics of cabergoline in patients harboring prolactino...

Objective: Pregnancy-related osteoporosis is a rare disorder with potentially severe complications. There is lack of clinical practice guidelines due to low incidence of this disease and few published cases.Material and methods: We present eight cases of pregnancy-related osteoporosis in women aged between 28–42 years. Six of them were diagnosed between 1 month and 3 years postpartum and two were diagnosed in the third trimester of pregnancy. Most o...

Introduction: Measurement of copeptin is proposed for use in the differential diagnosis of polyuric syndrome.Aims: To evaluate the diagnostic value of copeptin levels in patients with polyuria syndrome.Materials and methods: The study included 17 patients with central diabetes insipidus (CDI), 3 patients with nephrogenic diabetes insipidus (NDI), 7 patients with primary polydipsia (PP) and 26 control subjects. In all individuals bl...

According to state statistics service, Russia’s population in 2018 is more than 146.8 mil people. The total prevalence of acromegaly may range between 2.8 and 13.7 cases per 100,000 people and the annual incidence rates vary between 0.2 and 1.1 cases per 100,000 people (Lavrentaki A, et al. 2016). The epidemiological data for acromegaly in Russian population is lacking. The Russian hypothalamic and pituitary tumors registry was founded in 2004 and for 2018 it con...