Searchable abstracts of presentations at key conferences in endocrinology

ea0041ep134b | Bone & Osteoporosis | ECE2016

Negative correlation of osteocalcin with insulin resistance, but not with body fat, in lamin-mutated lipodystrophies

Leclerc Marion , Benomar Kanza , Lion George , Douillard Claire , Vigouroux Corinne , Pigny Pascal , Vantyghem Marie-Christine

Bone is involved in both phosphate-calcium and energetic metabolism. Osteocalcin, secreted by the osteoblasts, stimulates insulin secretion and improves insulin sensitivity. FGF-23, secreted by the osteoclasts, increases phosphate urinary excretion and is a marker of insulin resistance. Relationship between insulin-resistance, body fat and bone metabolism remains unclear. Therefore, the aim of this study was to evaluate osteocalcin and FGF-23 levels in diseases differing by bo...

ea0037ep627 | Obesity and cardiovascular endocrinology | ECE2015

Irisin/leptin ratio, a biological marker of lean/fat mass, may help to identify LMNA-mutated familial partial lipodystrophies

Bensmaine Faiza , Mapihan Kristell Le , Bourry Samuel , Lion Georges , Vigouroux Corinne , Pigny Pascal , Vantyghem Marie Christine

Irisin is a myokine correlated with lean body mass, despite its association with cardiovascular events (Mantzoros 2014). Increased muscle volume and lipoatrophy have been reported in female FPLD (Ji JCEM 214). Our aim was to determine whether irisin could help to distinguish certain lipodystrophic obesities from FPLD.Methods and patients: Circulating irisin levels (EIA Phoenix) were measured in 20 LMNA-related FPLD, 19 normal-weighed controls (H) and 13 ...

ea0037ep1204 | Clinical Cases–Pituitary/Adrenal | ECE2015

Familial SDHC mutation associated with prolactin/gh-secreting pituitary adenoma and paraganglioma

Barigou Mohammed , Buffet Alexandre , Bennet Antoine , Pigny Pascal , Bellec Laurent , Caron Philippe , Vezzosi Delphine

Introduction: SDH genes mutations are associated with hereditary phaeochromocytoma and paraganglioma syndromes. We describe the case of a patient with SDHC related familial paraganglioma and pituitary adenoma.Case: A 65-year old man consulted for an incidentally discovered 7 cm abdominal mass on CT-scan, lateral to the right kidney, invading inferior vena cava, associated to a retroperitoneal adenomegaly and a lesion on the body of L2 vertebra with spina...

ea0049oc5.3 | Cardiovascular Endocrinology | ECE2017

Cardio metabolic assessment of lamin A/C mutation carriers according to R482 or Non-R482 mutation

Kwapich Maxime , Benomar Kenza , Espiart Stephanie , Belle Eric Van , Pigny Pascal , Bonne Gisele , Vigouroux Corinne , Lacroix Dominique , Vantyghem Marie-Christine

Background: Lamin A/C mutations show heterogeneous phenotypes expanding from cardiopathies to lipodystrophies. LMNA-related heart disease has recently been shown to be associated with a high incidence of phenotypic progression and adverse arrhythmic and non-arrhythmic events. Anticipatory planning to prevent sudden death has been recommended in a multicentric cardiologic recruitment. Nevertheless the specific cardiac prognosis of R482-LMNA mutated patients, the hot-spot for pa...

ea0020p190 | Endocrine tumours and neoplasia | ECE2009

Serum chromogranin A assay in the biological diagnosis of pheochromocytomas and/or paragangliomas: results in 146 patients

d'Herbomez Michele , Bauters Catherine , Caron Philippe , Do Cao Christine , Pigny Pascal , Leteurtre Emmanuelle , Carnaille Bruno , Wemeau Jean-Louis

The biological diagnosis of pheochromocytoma (P) and/or paraganglioma (Pgg) relies on the identification of excessive secretion of the metanephrines. Chomogranin A (CgA) is a general indicator of neuroendocrine tumours that is highly expressed in P and correlate with tumour mass and secretory activity. The CgA test could be indicated as a useful test in patients with false positive metanephrines results. The aim of our prospective bi-centre study, is to evaluate the performanc...

ea0041ep21 | Adrenal cortex (to include Cushing's) | ECE2016

Long-term metabolic evolution of a cohort of patients treated for adrenal insufficiency

Coralie Moutarde , Claire Douillard , Catherine Bauters , Christine Cortet , Christine Do Cao , Laurence Leclerc , Emilie Merlen , Pascal Pigny , Jean-Louis Wemeau , Marie-Christine Vantyghem

The aim of this retrospective study was to compare the long-term metabolic evolution of a cohort of patients treated for adrenal insufficiency (AI), and the best biological parameters of a good balance.Seventy patients with AI (mean age 41 years (±16); 60% female) were followed during a median 6-year period (2–16 years): 38 after bilateral adrenalectomy (60% Cushing) and 32 after AI of medical origin (62% polyglandular autoimmune syndrome). BMI...

ea0081p140 | Pituitary and Neuroendocrinology | ECE2022

Efficacy of lanreotide 120 mg primary therapy on tumor shrinkage and ophthalmologic symptoms in acromegaly after one month

Benderradji Hamza , Elise Vernotte , Ares Gustave Soto , Jean Philippe Woillez , Romain Perbet , Melodie-Anne Karnoub , Benoit Soudan , Arnaud Jannin , Assaker Richard , Luc Buee , Prevot Vincent , Claude-Alain Maurage , Pascal Pigny , Marie-Christine Vantyghem , Emilie Merlen , Cortet Rudelli Christine

Introduction: Few studies to date have attempted to evaluate the early efficacy of first-generation somatostatin analogs in somatotroph macroadenomas.Objective: To investigate the short-term efficacy of primary therapy with lanreotide 120 mg on tumor shrinkage and ophthalmologic symptoms in newly diagnosed patients with acromegaly.Design and patients: This single-center retrospective study included 21 patients who were newly diagno...

ea0081p700 | Reproductive and Developmental Endocrinology | ECE2022

Fetal exposure to anti-müllerian hormone triggers a transgenerational epigenetic transmission of polycystic ovary syndrome (PCOS) defects in adulthood

Nour El Houda Mimouni , Paiva Isabel , Barbotin Anne-Laure , Ezzahra Timzoura Fatima , Plassard Damien , Le Gras Stephanie , Ternier Gaetan , Pigny Pascal , Catteau-Jonard Sophie , Simon Virginie , Prevot Vincent , Boutillier Anne-Laurence , Giacobini Paolo

Polycystic ovary syndrome (PCOS) is the most common endocrine and metabolic disorder affecting women in reproductive age. Women with PCOS exhibit 2-3x higher levels of circulating Anti-Müllerian Hormone (AMH) as compared to healthy women and it is unclear if the elevation of AMH is a bystander effect or is driving the condition. Moreover, PCOS has a strong heritable component, however the etiopathology of the disease and the mechanisms underlying its transmission remain t...

ea0081p182 | Reproductive and Developmental Endocrinology | ECE2022

Defining reference ranges for serum anti-Müllerian hormone (AMH) on a large cohort of normozoospermic adult men highlights new potential physiological functions of AMH on FSH secretion and sperm motility

Benderradji Hamza , Anne-Laure Barbotin , Maryse Leroy-Billiard , Julie Prasivoravong , Francois Marcelli , Christine Decanter , Geoffroy Robin , Valerie Mitchell , Jean-Marc Rigot , Antonino Bongiovanni , Florent Sauve , Luc Buee , Claude-Alain Maurage , Maryse Cartigny , Arnauld Villers , Vincent Prevot , Sophie Catteau-Jonard , Nicolas Sergeant , Paolo Giacobini , Pascal Pigny , Clara Leroy

Background: Few studies to date have attempted to measure serum anti-Müllerian hormone (AMH) levels in adult men, and solid references ranges have not yet been defined on a large cohort.Objective: In this study, we aimed to first establish the reference ranges for serum AMH and AMH-to-total testosterone ratio (AMH/tT) in adult males. Secondly, we investigated the relationship between serum AMH and both reproductive hormones and semen parameters....

ea0094p371 | Neuroendocrinology and Pituitary | SFEBES2023

GnRH neuronal disruption and hypotestosteronemia in COVID-19

Sauve Florent , Nampoothiri Sreekala , Clarke Sophie , Fernandois Daniela , Fernando Ferreira Coelho Caio , Dewisme Julie , G Mills Edouard , Ternier Gaetan , Cotellessa Ludovica , Iglesias Garcia Cristina , Mueller-Fielitz Helge , Lebouvier Thibaud , Perbet Romain , Florent Vincent , Baroncini Marc , Sharif Ariane , Ereno-Orbea June , Mercado-Gomez Maria , Palazon Asis , Mattot Virginie , Pasquier Florence , Catteau-Jonard Sophie , Martinez-Chantar Maria , Hrabovszky Erik , Jourdain Merce , Deplanque Dominique , Morelli Annamaria , Guarnier Giulia , Storme Laurent , Robil Cyril , Trottein Francois , Nogueiras Ruben , Schwaninger Markus , Pigny Pascal , Poissy Julien , Chachlaki Konstantina , Maurage Claude-Alain , Giacobini Paolo , S Dhillo Waljit , Rasika S , Prevot Vincent

Loss of gonadotropin-releasing hormone (GnRH) and cognitive deficits have recently been demonstrated by our group in conditions including Down syndrome and Alzhiemer’s disease. In some patients with COVID-19, olfactory and cognitive alterations persist, and persistent hypotestosteronemia in SARS-CoV-2-infected men could be a consequence of deficient GnRH. To understand whether neuroinvasion of GnRH system by SARS-CoV-2 could explain some post-COVID symptoms and thus resul...