Abstract Search

ea0028oc5.5 | Growth, tumours and pituitary | SFEBES2012

Role of the hypoxic signalling pathways in the histopathological prediction of malignancy in phaeochromocytomas and paragangliomas

Pinato David , Ramachandran Radha , Toloue Kalami Toussi Samin , Vergine Marco , Ngo Nyethane , Sharma Rohini , Khoo Bernard , Meeran Karim , Palazzo Fausto , Martin Niamh , Dina Roberto , Tan Tricia

Backgeound and Aims: Phaeochromocytomas (PCC) and paragangliomas (PGL) are mostly benign sympathoadrenal tumours. However, there are no available markers to predict a malignant course. Since hypoxia is involved in the pathogenesis of these tumours, we aimed to qualify the relevance of the mammalian Target of Rapamycin (m-TOR) and hypoxic pathways in benign and malignant PCC/PGL.Methods: Tissue microarray (TMA) blocks were constructed with 80 PCC/PGL, inc...

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ea0028p140 | Neoplasia, cancer and late effects | SFEBES2012

Expression of Somatostatin Receptors in Phaeochromocytoma and Paragangliomas

Parvizi Nassim , Alsafi Ali , Vergine Marco , Ramachandran Radha , Martin Niamh , Palazzo Fausto , Pinato David , Sharma Rohini , Meeran Karim , Dina Roberto , Tan Tricia

Background and Aims: Phaeochromocytoma and paragangliomas are neuroendocrine tumours arising from chromaffin cells. These tumours express somatostatin receptors (SSTRs), which has five different main subtypes (SSTR1, SSTR2, SSTR3, SSTR4 and SSTR5). The differential expression of the different receptor subtypes in these tumours has previously been reported with a small series of tumour samples. Our study examined the expression of SSTR subtypes in a larger series of benign and ...

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Endocrine Abstracts

Role of the hypoxic signalling pathways in the histopathological prediction of malignancy in phaeochromocytomas and paragangliomas

Expression of Somatostatin Receptors in Phaeochromocytoma and Paragangliomas

BiosciAbstracts