Searchable abstracts of presentations at key conferences in endocrinology

ea0070ep126 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Augmentation index in the assessment of pulse wave reflection assessment in lean and obese women with polycystic ovary syndrome (PCOS)

Alexandraki Krystallenia , Kandaraki Eleni , Papaioannou Theodoros , Piperi Christina , Argyris Antonis , Papamichael Christos , Protogerou Athnasios , Lekakis John

Objective: Conflicting findings have been published regarding the pressure wave reflection and the arterial stiffness in young women with PCOS as opposed to the overt ab initio presence of endothelial dysfunction compared with controls which can be reversed six months after metformin administration. The aim of this study was to investigate arterial stiffness and wave reflections in young women with polycystic ovary syndrome (PCOS) with respects to the different weight...

ea0032p411 | Diabetes | ECE2013

Advanced glycation end-products inhibit insulin signaling in human granulosa cells

Piperi Christina , Papageorgiou Efstathia , Kandaraki Eleni , Koutsilieris Michael , Diamanti-Kandarakis Evanthia

Introduction: AGEs have been shown to be accumulated in granulosa cell layer from human ovaries in normal and in women with polycystic ovarian syndrome (PCOS) and insulin resistance. AGEs interfere with insulin signaling pathways of several target tissues and are implicated in insulin resistance mechanisms. There is evidence that within the ovary these pathways are also important for glucose metabolism and normal folliculogenesis. The effect of human glycated albumin (HGA) eit...

ea0022p721 | Signal transduction | ECE2010

Lysyl oxidase interacts with AGEs signaling to modulate collagen synthesis in polycystic ovarian tissue

Papachroni Katerina , Piperi Christina , Levidou Georgia , Korkolopoulou Penelope , Pawelczyk Leszek , Diamanti-Kandarakis Evanthia , Papavassiliou Athanasios

The connective tissue components, collagen types I, III and IV, which surround the ovarian follicles, undergo drastic changes during ovulation. Abnormal collagen synthesis and increased volume and density of ovarian stroma characterise the polycystic ovary syndrome (PCOS). Physiologically, collagen synthesis in ovarian follicles is partly regulated by lysyl oxidase (LOX), which catalyzes the collagen and elastin cross-linking and plays indispensable role in the organization of...

ea0016p254 | Diabetes and cardiovascular diseases | ECE2008

Increased serum AGEs is a distinct finding in lean women with PCOS

Diamanti-Kandarakis Evanthia , Katsikis Ilias , Piperi Christina , Kandaraki Eleni , Piouka Athanasia , Papavassiliou Athanasios , Panidis Dimitrios

In insulin resistant, young women with PCOS elevated serum AGEs and their receptor RAGE have been reported. The present study (approved by the local ethical committee) was undertaken to determine whether increased levels of serum AGEs in PCOS is a distinct finding compared with age- and BMI-matched women, presenting the isolated components of the syndrome and whether serum AGE levels were different among PCOS phenotypes. A total of 193 lean non-insulin resistant women were stu...

ea0016p649 | Reproduction | ECE2008

Accumulation of dietary glycotoxins in the reproductive system of normal female rats

Diamanti-Kandarakis Evanthia , Piperi Christina , Kandaraki Eleni , Korkolopoulou Penelope , Patsouris Efstratios , Papalois Apostolos , Papavassiliou Athanasios

The present study aimed to investigate whether dietary advanced glycation end-products (AGEs) are detected in the ovarian tissue of normal female rats and whether they affect metabolic or hormonal profile.Normal rats were randomly assigned to regular diet, high (H-AGE) or low (L-AGE) content for 6 months. Age-matched rats fed with regular diet served as controls.H-AGE rats, demonstrated higher levels of fasting glucose (P&#6...

ea0016p170 | Comparative endocrinology | ECE2008

Serum levels of the soluble isoform of the receptor of advanced glycosylated end products (sRAGE) are increased in women with PCOS

Piperi Christina , Tantalaki Evangelia , Livadas Sarantis , Christakou Claire , Xirafis Xenophon , Adamopoulos Christos , Kandarakis Stelios , Papavassiliou Athanasios , Diamanti-Kandarakis Evanthia

Serum levels of soluble RAGE (sRAGE total), the soluble isoform of the receptor of advanced glycated end products (AGEs) that lacks the transmembrane and intracytoplasmic domains of RAGE, has been found elevated in type 2 diabetics and non diabetic subjects and positively correlated with AGEs levels. In women with PCOS, while serum AGEs have been demonstrated to be elevated, sRAGE levels have not been determined as yet.The aim of the present study was to...

ea0016p171 | Comparative endocrinology | ECE2008

Effects of dietary advanced glycation end products on endocrine and metabolic parameters of women with polycystic ovarian syndrome

Tantalaki Evangelia , Piperi Christina , Koulouri Katerina , Livadas Sarantis , Argyrakopoulou Giouli , Economou Fragkiskos , Mpoutzios Giorgos , Papavassiliou Athanasios , Diamanti-Kandarakis Evanthia

In female rats, diet enriched in advanced glycation end products (AGEs) has been associated with increased serum testosterone levels and deposition of dietary glycotoxins in ovarian tissue.Women with PCOS present increased serum AGE levels, which are acutely elevated after intake of a single meal high in AGE content. In this study the effects of a hypocaloric diet and an AGE-enriched hypocaloric diet were investigated, on the endocrine and metabolic prof...

ea0016p257 | Diabetes and cardiovascular diseases | ECE2008

Cytokines secretion in long-standing diabetes mellitus type 1 and 2: associations with low-grae systemic inflammation

Alexandraki Krystallenia I , Piperi Christina , Ziakas Panayiotis D , Apostolopoulos Nikolaos V , Makrilakis Konstantinos , Syriou Vassiliki , Diamanti-Kandarakis Evanthia , Kaltsas Gregory A , Kalofoutis Anastasios

Background: Low-grade systemic chronic inflammation has been recognized in diabetes. The purpose of this study was the assessment of proinflammatory cytokines secretion profile in long-standing diabetes along with the presence of systemic inflammation.Methods: Twenty patients with type 1 (T1DM: 7 women, age (±S.E.M.): 30.90±1.93 years, duration of disease: 142.47±28.34 months) and 21 patients with type 2 diabetes mellitus T2...

ea0056gp87 | Diabetes Epidemiology | ECE2018

Differential expression of apoptotic and low grade inflammatory markers in Alzheimer’s disease compared to diabetes mellitus type 1 and 2

Alexandraki Krystallenia , Apostolopoulos Nikolaos , Adamopoulos Christos , Stamouli Evangelia , Dalagiorgou Georgia , Papaioannou Theodoros , Analitis Antonios , Karamanou Marianna , Makrilakis Konstantinos , Politis Antonios , Piperi Christina

Objective: Neuroinflammation is a common primary or secondary mediator of the neurodegenerative process accompanying Alzheimer’s disease (AD). Impaired brain insulin signaling, defining brain insulin resistance may represent a link between AD and type 2 diabetes mellitus (T2DM) while neuronal apoptosis may also be involved in the inflammatory process. Peripheral cytokine levels of IL-1β, IL-6, TNFα along with high sensitivity C-reactive protein (hsCRP) and apopt...