Searchable abstracts of presentations at key conferences in endocrinology

ea0081p679 | Pituitary and Neuroendocrinology | ECE2022

Efficacy, safety and metabolic impact of long-term pegvisomant therapy in acromegaly: results from a 10-year single center experience

Pirchio Rosa , Simona Auriemma Renata , Elena Montini Maria , Vergura Alice , Pivonello Rosario , Colao Annamaria

Pegvisomant (PEG) is effective in acromegaly control and exerts a positive impact on glucose metabolism. The current study aimed at investigating the effects of 10-years PEG treatment on disease control, pituitary adenoma size, and metabolic profile in patients with acromegaly resistant to somatostatin analogues (SRLs). Twenty-two patients (9 men,13 women, age 45.54 ± 12.83 years) treated with PEG for 10 years, in monotherapy or in combination with SRLs, were included in ...

ea0081p680 | Pituitary and Neuroendocrinology | ECE2022

Long-term pasireotide therapy: real life experience of a single referral center

Pirchio Rosa , Vergura Alice , Elena Montini Maria , Simona Auriemma Renata , Pivonello Rosario , Colao Annamaria

Pasireotide is a second-line therapy for acromegaly, that allows to obtain disease control in patients previously uncontrolled. However, pasireotide-induced hyperglycemia is of major concern. Currently, few data concerning prolonged use of pasireotide are available. The current retrospective study aimed at investigating the efficacy and safety of long-term pasireotide therapy. Sixteen consecutive patients (5 males, 11 females, age 47 ± 11 years) undergoing pasireotide for...

ea0081p682 | Pituitary and Neuroendocrinology | ECE2022

Berlin questionnaire and epworth sleepiness scale as screening tools of sleep apnea risk in patients with acromegaly: comparison of 144 patients and an age-and gender-matched health cohort

Pirchio Rosa , Addato Raffaele , Elena Montini Maria , Valentina De Santis Ciacci Corina , Vergura Alice , Simona Auriemma Renata , Pivonello Rosario , Colao Annamaria

Sleep apnea (SA) is a common acromegaly comorbidity, influencing patientsÂ’ quality of life and mortality risk. Despite its importance, SA frequently remains undiagnosed, and its real prevalence seems to be underestimated. The current observational study aimed at investigating the role of Berlin questionnaire (BQ) and Epworth sleepiness scale (ESS) in assessing the risk of SA in this high-risk population, and to compare the results with an age-and gender-matched health coh...

ea0070aep744 | Pituitary and Neuroendocrinology | ECE2020

Pasireotide-induced hyperglycemia and efficacy of antidiabetic treatments in patients with acromegaly: Evaluation of two referral centers

F.S. Grasso Ludovica , Chiloiro Sabrina , Pirchio Rosa , Giampietro Antonella , Auriemma Renata S. , Bianchi Antonio , De Martino Maria Cristina , Negri Mariarosaria , Colao Annamaria , Pontecorvi Alfredo , De Marinis Laura , Pivonello Rosario

Pasireotide (PAS) has a safety profile similar to first-generationsomatostatin analogues (SSA), except for a higher frequency of hyperglycaemia-related adverse events (AEs). However, consensus on the best management of PAS-induced hyperglycaemia in acromegalic patients has still to be defined. The current study aims at investigating the effects of long-term PAS treatment on glucose metabolism, by evaluating the clinical management of hyperglycemia-relatedAEs in acromegalic pat...

ea0081p664 | Pituitary and Neuroendocrinology | ECE2022

Impact of COVID-19 lockdown in patients with acromegaly: an Italian multicenter experience

Pirchio Rosa , Simona Auriemma Renata , Cambria Valeria , Gatto Federico , Carosi Giulia , Ragonese Marta , Guarnotta Valentina , Ceccato Filippo , Cozzolino Alessia , Mongioi Laura , Prencipe Nunzia , Nista Federica , Del Sindaco Giulia , Calogero Aldo , Isidori Andrea , Scaroni Carla , Giordano Carla , Ferrau Francesco , Mantovani Giovanna , Ferone Diego , Grottoli Silvia , Iasevoli Felice , Colao Annamaria , Pivonello Rosario

Over the last two years, COVID-19 outbreak and lockdown have exerted a remarkable psychological burden in the general population. Such an impact is supposed to be even worse in acromegaly, known to induce a severe psychological impairment due to its somatic disfigurements and systemic comorbidities. The current observational study aimed at investigating the impact of COVID-19 outbreak and lockdown on psychological health in acromegalic patients as compared to non-acromegalic h...