Searchable abstracts of presentations at key conferences in endocrinology

ea0084op-03-16 | Oral Session 3: Advanced Thyroid Cancer | ETA2022

A clinical and molecular study of a real-world cohort of braf v600e anaplastic thyroid carcinoma treated with dabrafenib and trametinib

Nunes da Silva Tiago , Rodrigues Ricardo , Rito Miguel , Saramago Ana , Pires Carolina , Horta Mariana , Leite Valeriano , Cavaco Branca

Introduction and objectives: Anaplastic thyroid cancer (ATC) has a very low overall survival (OS) and progression free survival (PFS) due to fast growth and resistance to non-target therapies. A recent phase II study showed a dramatic increase in OS and PFS of BRAF V600E mutated ATC patients treated with Dabrafenib and Trametinib (DT). However as commonly reported in melanoma durable responses in ATC may be compromised by resistance mechanisms. Until now only a few ca...

ea0035p1008 | Thyroid (non-cancer) | ECE2014

Recurrence of Graves' disease after radioiodine treatment: factors related to treatment failure

Moreno Carolina , Pires Luis , Cardoso Luis , Ruas Luisa , Saraiva Joana , Guelho Daniela , Vicente Nuno , Costa Gracinda , Carrilho Francisco

Introduction: Radioiodine (RAI) therapy is an inexpensive and reliable therapeutic option for GravesÂ’ disease (GD). However, individual characteristics of the disease can influence therapeutic success. The identification of these factors may help to predict outcome and select optimal pre-treatment conditions.Aim: To assess clinical, laboratory and radioactive parameters that may lead to RAI treatment failure in patients with GD....