ea0003oc16 | Endocrine Neoplasia | BES2002
Lee A
, Cosgrove K
, Barnes P
, Lindley K
, Aynsley-Green A
, de Tullio P
, Pirotte B
, Lebrun P
, Dunne M
Diazoxide is an agonist of ATP sensitive K+ (KATP) channels in beta-cells and is used in the treatment of hyperinsulinism caused by insulinomas or Hyperinsulinism in Infancy (HI). The responsiveness of patients to diazoxide is highly variable and complicated by side-effects which include hypertension and hypertrichosis. The aim of this study was to examine the actions of a novel benzothiadiazine-derivative, BPDZ-154, on beta-cell KATP channels and insulin release. W...