Searchable abstracts of presentations at key conferences in endocrinology

ea0055wa9 | Workshop A: Disorders of the hypothalamus and pituitary (I) | SFEEU2018

Acute onset DI in a young woman

Pittaway James , Drake William

A 31 year-old lady presented to clinic with an acute, three-week history of rapidly worsening polyuria and polydipsia. She described an eighteen month history of dysmenorrhoea with no galactorrhoea and reported no change in her vision. Her past medical history included alopecia areata one year previously from which she made a full recovery. Clinical examination was normal including full visual fields to red-pin confrontation. Biochemistry identified serum sodium of 141 mmol/l,...

ea0048cb8 | Additional Cases | SFEEU2017

Androgen deprivation in testicular cancer by way of macroprolactinoma – balancing the two pathologies

Pittaway James , Shamash Jonathan , Drake William

Case history: A 72 year old gentleman from Zimbabwe presented to clinic with MRI pituitary findings of 1.5×1.4×1 cm pituitary macroadenoma. This had been discovered incidentally during outpatient investigation for severe headaches refractory to standard analgesia at another hospital. The mass was in contact with but not compressing the optic chiasm. He did not describe any visual loss. He had an unintentional weight loss of 10 kg in the last 2 months. He described de...

ea0055we14 | Workshop E: Disorders of the adrenal gland | SFEEU2018

Hyporeninaemic hypoaldosteronism in surgically cured Conn’s syndrome

Pittaway James , Coppack Simon , Carpenter Rob , Drake William

A 53 year old gentleman from Ghana was referred to our clinic for further management of his Conn’s syndrome. This had been diagnosed at another hospital 3 years previously when he presented with hypertension and hypokalaemia on the back of 14 years of poorly controlled hypertension. Serum aldosterone was raised at 3178 pmol/l and serum renin mass was 3.9 mU/l. MRI revealed a 5 mm nodule in the medial limb of the right adrenal gland. He was initially commenced on medical t...

ea0028p50 | Clinical practice/governance and case reports | SFEBES2012

Barts Endocrine Telephone Advice Clinic (ETAC): utilisation and outcomes from the first 18 months

O'Toole Sam , Pittaway James , Gunganah Kirun , Druce Maralyn

Background: In May 2010 a dedicated Consultant-delivered Endocrine Telephone Advice Clinic (ETAC) was launched at St Bartholomew’s Hospital as a direct point of access for primary care doctors to obtain endocrine advice about new patients. The proposed benefits of this clinic were to: 1. Reduce unnecessary clinic attendances that could be managed in primary care. 2. Allow for more detailed and less hurried discussions of non-urgent cases than was possible via the on-call ...

ea0048wh2 | Workshop H: Miscellaneous endocrine and metabolic disorders | SFEEU2017

An unusual presentation of multiple endocrine neoplasia 1 (MEN1)

Pittaway James , Sahdev Anju , Harrison Barney , Newell-Price John , Drake William

Case history: A 36 year-old man was referred to our department for further evaluation of a large adrenal and multiple liver mass lesions. These had been found on an abdominal ultrasound requested for a 3 week history of mild, episodic abdominal pain. He was asymptomatic but described mild night sweats for over 10 years.Investigations, results and treatment: Hyperparathyroidism was evident, with a serum corrected calcium 3.04 mmol/l (2.15–2.65), PTH ...

ea0028p6 | Bone | SFEBES2012

Recurrent pancreatitis in patient with Familial Hypocalciuric Hypercalcaemia (FHH) sucessfully treated with cinacalcet

Gunganah Kirun , Pittaway James , Raja Omair , O'Toole Sam , Druce Maralyn , Grossman Ashley

Case: A 22 year-old female student presented with a history of recurrent pancreatitis since 2007. The most common causes of pancreatitis, including drugs, gallstones, corticosteroids, excess alcohol and hypertriglyceridaemia were excluded. She was noted to have elevated serum calcium, which was considered to be the cause of her pancreatitis, with a detectable serum PTH level. An initial diagnosis of primary hyperparathyroidism was made. However, two neck explorations failed to...

ea0028p77 | Clinical practice/governance and case reports | SFEBES2012

Haemofiltration as a treatment for severe, resistant hypercalcaemia

Pittaway James , Raja Omair , O'Toole Sam , Gunganah Kirun , Srirangalingam Umasuthan , Hanson Philippa , Drake William

Introduction: We describe two patients admitted to our institution with severe hypercalcaemia, resistant to conventional treatment, requiring haemofiltration. Patient 1 was admitted to hospital with profound hypercalcaemia (5.8 mmol/L) secondary to primary hyperparathyroidism (PTH >263 Pmol/L). The hypercalcaemia had been discovered on a surgical admission 3 months previously and was being managed with 0.9% normal saline and pamidronate infusions at an outside hospital. On...

ea0031p358 | Thyroid | SFEBES2013

Prevalence of anti-thyroglobulin antibodies, their prognostic significance and impact on patient care in a cohort of patients with differentiated thyroid cancer

O'Toole Sam , Pittaway James , Raja Omair , Buckland Matthew , Plowman Nick , Brennan Carmel , Waterhouse Mona , Akker Scott , Drake Will , Druce Maralyn

Background: The measurement of thyroglobulin (Tg) is important in the follow-up of patients with differentiated thyroid cancer (DTC), but interpretation is subject to interference by anti-thyroglobulin antibodies (TgAb). National guidelines recommend measurement of TgAb status but no consensus exists on how surveillance should be adapted in cases of TgAb positivity.Aims: To evaluate the impact of TgAbs on clinical management, in a single-centre cohort of...

ea0094p175 | Adrenal and Cardiovascular | SFEBES2023

Laparoscopic adrenalectomy for phaeochromocytoma in the context of acute coronary syndrome

Soruna Omolayo , Plowman Christina , Yu Thinn , Pittaway James , Goodchild Emily , Wragg Andrew , Fitchat Tracey , Parvanta Laila , Akker Scott

A 54-year-old man presented to the heart attack centre with cardiac chest pain, vomiting and collapse. Biochemistry (troponin incremented from 117 to 315ng/l) and electrocardiogram confirmed a diagnosis of non-ST elevation myocardial infarction (NSTEMI). Past medical history included type 2 diabetes mellitus and hypertension (diagnosed 8 years previously), hypercholesterolaemia and a 20 pack year smoking history. Secondary prevention for MI was commenced and coronary angiograp...

ea0086op2.4 | Adrenal and Cardiovascular | SFEBES2022

Delta-like non-canonical notch ligand 1 (DLK1)-expressing adrenocortical progenitor cells: role in adrenal turnover, remodeling and tumorigenesis in mice

Mariniello Katia , Pittaway James , Hadjidemetriou Irene , Borges Kleiton , Doroszko Milena , Doghman Mabrouka , Lalli Enzo , Rahman Nafis , Breault David , Rognoni Emanuel , Guasti Leonardo

The adrenal cortex is a dynamic organ that undergoes self-renewal. In the mouse it is divided into two concentric layers, the outer zona glomerulosa (ZG) and the inner zona fasciculata (ZF), that secrete aldosterone and corticosterone, respectively. Capsular and subcapsular stem/progenitor cells differentiate and migrate in a centripetal fashion to repopulate the gland until they reach the juxtamedullary region where they undergo senescence and apoptosis. Our lab has previousl...